INTRODUCTION While corticosteroids are an effective choice of treatment for severe vernal keratoconjunctivitis (VKC), their long-term use is restricted due to side effects. This study was conducted to evaluate the efficacy and safety of topical cyclosporine A (CsA) 0.05% in the treatment of VKC. METHODS A total of 30 patients with VKC that was resistant to topical corticosteroids, antihistami...

BACKGROUND Treatment of oral lichen planus (OLP) is a major challenge for clinicians and patients. There is limited scientific evidence about topical treatment with retinoids. We conducted a literature review of data on the effectiveness and safety of topical retinoids in OLP patients. MATERIALS AND METHODS We searched the MEDLINE, Embase and Cochrane databases for articles on topical retinoi...

purpose : to report a case of bilateral dense ring-shaped marginal keratitis after photorefractive keratectomy (prk) case report : a 44-year-old man developed bilateral dense ring-shaped marginal keratitis after prk. the patient had moderate to severe meibomian gland dysfunction preoperatively that was treated incompletely. he was treated with mild topical antibiotics, topical and systemic ster...

Background: Diaper rash is a common but non life threatening condition during infancy. Different modalities of treatment are suggested. Sucralfate acts as a physical barrier to irritants and has antibacterial activities. Promising reports of the effect of topical sucralfate on wound epithelialization along with its bacteriostatic properties led us to carry out a trial to evaluate its role as a ...

AIM To evaluate topical mitomycin C (MMC) chemotherapy in the treatment of conjunctival melanoma and primary acquired melanosis with atypia. METHODS In a phase I clinical trial, 10 patients with conjunctival melanoma and/or primary acquired melanosis with atypia were treated with topical MMC 0.04% four times daily. Four patients were given MMC for 28 days as a primary treatment. Six patients ...

purpose: to report two cases of bilateral bacterial keratitis as a sight-threatening complication following photorefractive keratectomy (prk) patients and findings: the first case was a 45-year-old man referred due to bilateral ocular pain and purulent discharge two days after bilateral prk. based on his clinical picture, smear and cultures from both corneal ulcers were taken with a diagnosis o...

keloids are aesthetically disfiguring and severely disabling. the optimal treatment remains undefined. this clinical study, evaluate the efficacy and side effects of combined topical silicone and 5-fluorouracil on the prevention of keloids. in this double blind randomized clinical trial, fifty patients with keloids were randomly allocated in two groups. the control group were treated by periles...

Background and Purpose: Vitamin C is administered orally or intravenously for the treatment of burn wounds. However, effects of the topical application of vitamin C remain unclear. This study aimed to evaluate the effects of topical vitamin C solution on the necrotic tissue volume of second-degree burn wounds. Methods: This clinical trial was conducted on 30 patients with second-degree burns a...

PURPOSE Eczema may flare because of bacterial infection, but evidence supporting antibiotic treatment is of low quality. We aimed to determine the effect of oral and topical antibiotics in addition to topical emollient and corticosteroids in children with clinically infected eczema. METHODS We employed a 3-arm, blinded, randomized controlled trial in UK ambulatory care. Children with clinical...

PURPOSE To report the resolution of symptoms and signs of chronic dry eye for at least 1 year after completion of a minimum 6-month course of topical 0.05% cyclosporine in a subgroup of patients from 2 practices. DESIGN Retrospective case series. PARTICIPANTS Eight patients who had had chronic dry eye disease for 3 to 20 years were treated with topical cyclosporine for 6 to 72 months, and t...