The field of immunotherapy in cancer treatments has been accelerating over recent years and has entered the forefront as a leading area of ongoing research and promising therapies that have changed the treatment landscape for a variety of solid malignancies. Prior to its designation as the Science Breakthrough of the Year in 2013, cancer immunotherapy was active in the treatment of hematologic ...

background: the adjuvanticity potential of lactobacillus casei was first suggested in an old survey. the present study was designed to investigate the efficacy of a new immunotherapy against breast cancer made by mixing an extract of heated 4t1 mammary carcinoma cell line and a heat-killed preparation of lactobacillus casei. methods: female balb/c mice (6–8 weeks old, n=40) were challenged subc...

Allergen immunotherapy can desensitize even subjects with potentially lethal allergies, but the changes induced in T cells that underpin successful immunotherapy remain poorly understood. In a cohort of peanut-allergic participants, we used allergen-specific T-cell sorting and single-cell gene expression to trace the transcriptional "roadmap" of individual CD4+ T cells throughout immunotherapy....

Sublingual immunotherapy is gaining widespread attention as a viable alternative to subcutaneous immunotherapy for the treatment of allergic rhinoconjunctivitis. In addition, sublingual immunotherapy has been studied in other allergic disorders including asthma. However, a review of published studies indicates that there are deficiencies and considerable heterogeneity in both design and data in...

background: recently, the use of granulocyte colony-stimulating factor (g-csf) has been proposed to improve pregnancy outcomes in reproductive medicine. objective: a systematic review of the current use of g-csf in patients who have difficulty conceiving and maintaining pregnancy was performed. materials and methods: two electronic databases (pubmed/ medline and scopus) were searched. study sel...

The purpose of this study was to assess the clinical efficacy mogamulizumab in combination with systemic interferon, retinoids, and/or extracorporeal photopheresis for patients advanced cutaneous T-cell lymphoma. There are limited treatment options CTCL refractory previous therapies. At our center, has been combined other immunotherapies an enhanced synergistic effect these patients. This a ret...

the current treatment of choice for cutaneous leishmaniasis is either parenteral or intralesional antimonial compounds. each of these treatments has its own downfalls which include toxic side effects with the parentral injection and pain at the site of injection with the intralesional injection. in recent years, there has been more focus on paromomycin as an alternative drug; however, current d...

sublingual allergen immunotherapy (slit) is considered to be safer and more convenient than subcutaneus immunotherapy. slit trials with house dust mites involving patients with allergic rhinitis (ar) and asthma reported discordant results. the aim of the study was to investigate the clinical efficacy and safety of slit with dermatophagoides pteronyssinus (d.pt) extract produced in serbia and pa...

Psoriasis (PSO) is a chronic inflammatory condition characterized by erythematous plaques. Treatment of this varies from topical treatments to immunotherapies. In the Philippines, most programs that offer immunotherapy require tissue diagnosis. Hence, dermatopathologists have an important role in managing these patients, especially cases where PSO histopathology deviates classic features. This ...