Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferation and aberrant differentiation of keratinocytes, inflammation in dermis epidermis leukocyte infiltration Th1-like cytokine pattern. An experimental mechanism-based vitro model has been developed using novel multi-compartment reconstructed full-thickness (3C System Episkin SA) applying systemically mixture Th-1 c...

BACKGROUND Daivobet is a once-daily treatment of psoriasis vulgaris containing betamethasone dipropionate and calcipotriol in a new ointment vehicle. OBJECTIVE To assess the cost-effectiveness of once-daily treatment with Daivobet (4 weeks) followed by calcipotriol (4 weeks) compared to tacalcitol (8 weeks). METHODS Resource utilization was assessed within a double-blind 8-week clinical tri...

niosomes are non-ionic surfactant vesicles that have potential applications in the delivery of hydrophilic and hydrophobic drugs. the topical form of n-acetyl glucosamine (nag) recently has been considered in the treatment of hyperpigmentation disorders due to its inhibitory effect on thyrosinase enzymes in melanocytes. to improve nag penetration into the skin we formulated the drug in niosomes...

pterygium is characterized by an elastic degeneration of the conjunctiva that extends across the limbos and invades the cornea. the recurrence rate is varied from 25-80% after primary closure to 6% with free conjunctival and iimbal grafts. several adjunctive therapies have been investigated for recurrent pte¬rygium. this article presents a 52-year-old athletic man who was seen for evaluation of...

Diastereomeric and geometric analogs of calcipotriol, PRI-2202 and PRI-2205, were synthesized as advanced intermediates from vitamin D C-22 benzothiazoyl sulfones and side-chain aldehydes using our convergent strategy. Calcitriol, calcipotriol (PRI-2201) and tacalcitol (PRI-2191) were used as the reference compounds. Among a series of tested analogs the diastereomeric analog PRI-2202 showed the...