Pulmonary hypertension (PH) is a pathophysiological condition of increased pulmonary circulation vascular resistance due to various reasons, which mainly leads right heart dysfunction and even death, especially in critically ill patients. Although drug interventions have shown some efficacy improving the hemodynamics PH patients, mortality rate remains high. Hence, identification new targets tr...

introduction: the phenomenon of climate change and its consequences is a familiar topic which is associated with natural disasters such as, flooding, hurricane, drought that cause water crisis and irreparable damages. studying this phenomenon is a serious warning regarding the earth’s weather change for a long period of time. materials and methods: in order to understand and survey the impacts ...

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a disease that may cause severe bleeding complications with risk of perinatal death or lifelong disability. The main cause of FNAIT is maternal antibodies against human platelet antigen (HPA)-1a. Both fetomaternal bleeding and transplacental trafficking of fetal cells during pregnancy could be the cause of alloimmunization. Persistence o...

Heatwaves are an extreme meteorological event in which affected populations may also be exposed to deteriorated air quality conditions due the increase pollutant concentrations, such as PM10 (particulate matter < 10 µg/m3). In order identify heatwaves (1973–2019) region of Faro (Algarve) during hot season (April–September), Excess Heat Factor (EHF) index was applied. The Mann–Kendall test re...

introduction: the activity of hypothalamus-pituitary-adrenal (hpa) axis is increased following inflammation due to its closed relation with immune system. this axis indicates an increased secretion of acth, and corticosterone during acute inflammation while little is known about its activity during chronic inflammation such as rheumatoid arthritis (ra). in this study we measured the products of...

Abstract July-September rainfall is a key component of Ethiopia’s annual and source variability throughout inland Greater Horn Africa. In this study we investigate the relative influences Mascarene (MH) South Atlantic (AH) highs on in covarying region Africa using CHIRPS observed ERA5 reanalysis. We show that mixed metric circulation at 850 hPa these two subtropical anticyclones (AH-MH), better...

The occurrence of Indian summer monsoon rainfall (ISMR) during June to September, especially over the eastern Gangetic plain India, is lifeline for densely residing people. intraseasonal and interannual variability in ISMR provokes drought flood conditions largely affects agriculture practices. Owing its importance, several studies on meteorological subdivisions, namely West Bengal (WB), Jharkh...

Polymorphism of human platelet antigens (HPAs) leads to alloimmunizations and immune-mediated platelet disorders including fetal-neonatal alloimmune thrombocytopenia (FNAIT), posttransfusion purpura (PTP), and platelet transfusion refractoriness (PTR). HPA typing and knowledge of antigen frequency in a population are important in particular for the provision of HPA-matched blood components for ...

BACKGROUND Immune thrombocytopenia is an immune disease characterized by thrombocytopenia and bleeding due to platelet antibodies against platelet membrane glycoproteins. Human platelet antigens are derived from polymorphisms of these glycoproteins. The aim of this study was to investigate human platelet antigen frequencies in immune thrombocytopenia patients from the state of Amazonas, Brazil ...