We describe the dynamics and the nature of the presymptomatic phase of multiple sclerosis (MS) in a patient for whom MR abnormalities suggestive of MS were found before the development of clinical symptoms. The patient was monitored with serial monthly MR imaging of the brain and spinal cord for 5 months. Disease activity during the presymptomatic phase showed imaging characteristics comparable...

BACKGROUND Gait metric alterations have been previously reported in patients suffering from chronic ankle instability (CAI). Previous studies of gait in this population have been comprised of relatively small cohorts, and the findings of these studies are not uniform. The objective of the present study was to examine spatiotemporal gait metrics in patients with CAI and examine the relationship ...

Methadone maintenance has been the treatment of choice for heroin addiction for several years. The prenatal and early neonatal effects have been described in several reports (Kandall et al. 1979; Finnegan 1983). However, there have been few reports on the longterm effects of methadone maintenance during pregnancy on the child’s somatic and neurobehavioral development. Some investigators have de...

Twenty-three infants with clinically proven bacterial meningitis were studied with real-time cranial sonography at the time of initial diagnosis and in several cases subsequently. A spectrum of sonographic abnormalities was observed, including bright convolutional markings, focal or diffuse increased and/or decreased parenchymal echoes, ventricular debris, and hydrocephalus. In three infants wi...

Although development of the full syndrome of kernicterus is relatively rare, neonatal jaundice continues to occur frequently. Controversy remains concerning whether or not infants with moderate elevations in bilirubin are at risk for neurodevelopmental disorders in later childhood. Sites of brain pathology associated with bilirubin neurotoxicity are identified and well established. Based on the...

OBJECTIVES To estimate the frequency of urinary problems among preschool children. METHODS In this cross-sectional study, 1000 preschool asymptomatic children attending the outpatient clinics of the Children's Hospital, Taif, Kingdom of Saudi Arabia between August 2013 and December 2013 were subjected to dipstick urine analysis. Microscopic examination was performed for the abnormal dipstick ...

BACKGROUND Medical history taking as well as Chlamydia antibody titre (CAT) testing are currently used in the selection of patients for diagnostic laparoscopy with tubal patency testing. Most research has focused on the predictive value of CAT in isolation from medical history. We assessed therefore whether the combination of medical history and CAT improves the efficiency of selecting patients...

This paper analyses the non linear properties exhibited by a drill string system under various un balanced mass conditions. The drill string is affected by continuous friction in the form of drill bit and well bore hole interactions. This paper proves the origin of limit cycling and increase of non linearity with increase in speed of the drilling in the presence of friction. The spectrum of the...

The first electroencephalographic (EEG) study in autism was published in 1964, and it reported EEG abnormalities in 58% of the autistic children studied [1], later research focused on epileptiform EEG abnormalities. In examining the prevalence of epileptiform abnormalities in all autistic patients, irrespective of clinical seizure history, wide variants in prevalence rates were obtained, rangin...

[Purpose] This study aimed to examine the effects of an 8-week modified Pilates program on the variability of inter-joint coordination in the elderly during walking. [Subjects and Methods] Twenty elderly participants with no recent history of orthopedic abnormalities (age, 67.9 ± 2.7 years; height, 163.7 ± 8.9 cm; weight, 67.1 ± 11.6 kg) were recruited for this study and randomly allocated to a...