To gain a deeper insight into cellular processes such as transcription and translation, one needs to uncover the mechanisms controlling the configurational changes of nucleic acids. As a step toward this aim, we present here a mesoscopic-level computational model that provides a new window into nucleic acid dynamics. We model a single-stranded nucleic as a polymer chain whose monomers are the n...

BACKGROUND The first stage in the implant of a total knee arthroplasty with computer-assisted surgery is to fasten the emitters to the femur and the tibia. These trackers must be hard-fixed to the bone. The objectives of our study are to evaluate the technical problems and complications of these tracker-pins, the necessary time to fix them to the bone and the possible advantages of a new femora...

We present a test scheduling methodology for core-based system-on-chips that allows tradeoff between system power dissipation and overall test time. The basic strategy is to use the power profile of non-embedded cores to find the best mix of their test pattern subsets that satisfy the power and/or time constraints. An MILP formulation is presented to globally perform the power-time tradeoff and...

We propose a novel, on-machine method of measuring the profile of the cutting edge of a tool by using the cutting fluid on the tool surface. Despite an environment of on-machine tool profile measurement, it is difficult to measure a cutting edge profile by using conventional optical methods due to interference from the cutting fluid on the tool surface. To overcome this problem, we propose a pr...

A simple, but not widely known, mathematical fact concerning the coverings of the full Lorentz group sheds light on parity and time reversal transformations of fermions. Whereas there is, up to an isomorphism, only one Spin group which double covers the orientation preserving Lorentz group, there are two essentially different groups, called Pin groups, which cover the full Lorentz group. Pin(1,...

OBJECTIVES To validate with an independent study that simple atrophy/postatrophic hyperplastic lesions (proliferative inflammatory atrophy [PIA]) often merge directly with high-grade prostatic intraepithelial neoplasia (PIN). METHODS Using radical prostatectomies (n =14), all high-grade PIN and adenocarcinoma lesions were identified. We examined the two-dimensional topographic relationship be...

This paper presents a new pseudo pin assignment algorithm for crosstalk noise control in multi-layer gridless general area routing. It also tends to minimize the number of vias needed in detailed routing. Our approach consists of two steps: coarse pseudo pin assignment and detailed pseudo pin assignment. Coarse pseudo pin assignment uses the crosstalk noise constraints to estimate the spacing r...

Since the introduction of the IGBT module, improvements in power loss have been achieved by applying new technologies. With the process improvements of the past few years in trench gate technology and light-punch-through vertical structures, it had been thought that the performance of the latest IGBT and pin diode silicon power devices had been brought as close to their theoretical limit as pos...

PURPOSE To conduct a prospective randomised controlled study to compare the stability and risk of nerve injury between fractures treated by medial-lateral pin fixation and those treated by 2-lateral pin fixation. METHODS Patients with displaced supracondylar fractures admitted between May 2000 and December 2001 were recruited into the study. They were randomised to treatment either with media...

Pin track-associated complications are almost universal findings with the use of external fixation. These complications are catastrophic if it leads to the failure of the bone-pin interface and could lead to pin loosening, fracture non-union and chronic osteomyelitis. Strategies proposed for the prevention and management of pin track complications are diverse and constantly changing. Prevention...