The purpose of this work is to explore and quantify physical metrics of breast tumors in both magnetic resonance imaging (MRI) and breast tomosynthesis (BT) images, and relate these metrics to pathophysiological and histopathological ndings. An analysis of breast specimens containing tumors will be employed to determine BT metrics of interest. These metrics will then be applied to patient image...

Studies have demonstrated a relationship between mammographic texture and breast cancer risk. To date, texture analysis has been limited by tissue superimposition in mammography. Digital Breast Tomosynthesis (DBT) is a novel x-ray imaging modality in which 3D images of the breast are reconstructed from a limited number of source projections. Tomosynthesis alleviates the effect of tissue superim...

We analyzed breast percent density (PD) estimated from 35 women with existing or recently detected abnormalities. Analyzed were digital mammograms (DM) and the central digital breast tomosynthesis (DBT) reconstructed slices. PD was estimated from the breast contralateral to cancer. We have examined the effect of modifying the DBT reconstruction filter on the accuracy of dense tissue segmentatio...

In order to investigate the effect of the number of projections on digital tomosynthesis image quality, images were acquired over a 40 degree arc and sampled into sets of 2 to 41 projections used as input to three different reconstruction algorithms, namely the shift-and-add, Feldkamp-Davis-Kress filtered back projection algorithms, and the simultaneous algebraic reconstruction technique. The v...

PURPOSE The low dose rate brachytherapy procedure would benefit from an intraoperative postimplant dosimetry verification technique to identify possible suboptimal dose coverage and suggest a potential reimplantation. The main objective of this project is to develop an efficient, operator-free, intraoperative seed detection technique using the imaging modalities available in a low dose rate bra...