Há mais de 30 anos estudiosos vêm observando uma tendência envelhecimento da população mundial. No Brasil, por exemplo, os estudos estimam que a idosos superará jovens até 2050. População essa tem demonstrado crescimento nos Estados Unidos também. Com o envelhecimento, sistema biológico humano afetado é nervoso central, incorrendo na redução dos neurônios e velocidade condução nervosa, limitaçõ...

In this study, we investigated the compositions of vitamin E tocochromanol [tocopherol (Toc) and tocotrienol (T3)] in crude refined rice bran oil (RBO) produced Japan other countries, including Brazil, Thailand, Vietnam, based on high-performance liquid chromatography analysis. All RBO analyzed contained ?-, ?- ?-Toc ?- ?-T3. Japanese RBO, although not also ?-T3. Furthermore, total Toc contents...

Cereal Chem. 77(5):551–555 Rice bran contains high amounts of beneficial antioxidants including tocopherols, tocotrienols, and oryzanols. Current rice milling technology produces rice bran from different layers of the kernel caryopsis. Under current practices, these layers are combined and then steam-extruded to form a stabilized rice bran pellet that is storage-safe prior to oil extraction. Ea...

The human vitamin D receptor (VDR) is a key nuclear receptor that binds nutritionally derived ligands and exerts bioeffects that contribute to bone mineral homeostasis, detoxification of exogenous and endogenous compounds, cancer prevention, and mammalian hair cycling. Liganded VDR modulates gene expression via heterodimerization with the retinoid X receptor and recruitment of coactivators or c...

BACKGROUND Tocotrienols, especially the gamma isomer was discovered to possess cytotoxic effects associated with the induction of apoptosis in numerous cancers. Individual tocotrienol isomers are believed to induce dissimilar apoptotic mechanisms in different cancer types. This study was aimed to compare the cytotoxic potency of alpha-, gamma- and delta-tocotrienols, and to explore their result...