نتایج جستجو برای: tme
تعداد نتایج: 1374 فیلتر نتایج به سال:
The outcome after resection for rectal cancers has improved following standardization of the surgical technique and the introduction of total mesorectal excision (TME) (1-4). In particular the TME technique has resulted in better local control and survival (5). The existence of nodal metastases has been the most important overall prognostic factor in determining long-term survival rates (6). Ad...
There has been enormous progress this past decade in the understanding of the biology of dendritic cells (DCs) along with increasing attention for the development of novel dendritic cell (DC)-based cancer therapies. However, the clinical impact of DC-based vaccines remains to be established. This limited success could be explained by suboptimal conditions for generating potent immunostimulatory...
Organ Preservation for Early Rectal Adenocarcinoma: The OPERA EuropeanTrial to Bring Robust Evidence
The curative treatment of rectal cancer is based on radical TME surgery. It is well admitted that abdomino-pelvic-resection (APR) is a severe body mutilation due to permanent stoma. More and more it is recognized that even low anterior resection (LAR) is not providing a very good quality of life because the LAR syndrome is often present and distressful [1]. For that reason a new way of clinical...
BACKGROUND T-cell checkpoint blockade and MEK inhibitor combinations are under clinical investigation. Despite progress elucidating the immuno-modulatory effects of MEK inhibitors as standalone therapies, the impact of MEK inhibition on the activity of T-cell checkpoint inhibitors remains incompletely understood. Here we sought to characterize the combined effects of MEK inhibition and anti-CTL...
In malignant tumors, cancer cells are embedded within a complex microenvironment consisting of the extracellular matrix (ECM), blood and lymphatic vessels, infiltrating leukocytes, fibroblasts, and other stromal cells. This microenvironment is characterized by abnormal physiologic conditions such as hypoxia and acidic extracellular pH, generated largely by the chaotic tumor vasculature and lack...
When a T cell infiltrates a tumor, it is subjected to a variety of immunosuppressive and regulatory signals in the microenvironment. However, it is becoming increasingly clear that due to the proliferative and energetically-deregulated nature of tumor cells, T cells also operate at a metabolic disadvantage. The nutrient dearth of the tumor microenvironment (TME) creates "metabolic checkpoints" ...
Introduction: Recurrent disease following colorectal cancer surgery will occur in about 30-50% of patients when considering both locoregional relapse and distant metastasis. For patients with rectal cancer, preoperative chemoradiotherapy followed by TME can provide durable 10-years overall survival (OS) of 58% and recurrence-free survival (RFS) of 62%. Background: Despite optimal treatment with...
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