Thrombotic microangiopathy (TMA) has been increasingly reported in human immunodeficiency virus (HIV)-infected humans over the past decade. The pathogenesis is unknown. We prospectively analyzed the renal pathology and function of 27 pigtailed macaques (Macaca nemestrina), infected intravenously with a virulent HIV-2 strain, HIV-2(287), in addition to that of four uninfected control macaques. N...

BACKGROUND Titanium-molybdenum alloy (TMA) and stainless steel (SS) wires are commonly used in orthodontics as arch-wires for tooth movement. However, plastic deformation phenomenon in these arch-wires seems to be a major concern among orthodontists. This study aimed to compare the mechanical properties of TMA and SS wires with different dimensions. MATERIAL AND METHODS Seventy-two wire sampl...

BACKGROUND Organic acid anhydride-induced occupational asthma is considered to be IgE-mediated. Airway and skin exposure are the two main routes of sensitization in the work place. Recently we developed an allergic asthmatic Brown Norway rat model sensitized by dermal exposure to trimellitic anhydride (TMA) using an occlusion patch application. OBJECTIVES The objectives of this study were (1)...

Our group recently discovered that certain dietary nutrients possessing a trimethylamine (TMA) moiety, namely choline/phosphatidylcholine and L-carnitine, participate in the development of atherosclerotic heart disease. A meta-organismal pathway was elucidated involving gut microbiota-dependent formation of TMA and host hepatic flavin monooxygenase 3-dependent (FMO3-dependent) formation of TMA-...

Dear Editor, Pauci-immune crescentic glomerulonephritis (Pauciimmune CGN) is the most common cause of CGN. Thrombotic microangiopathy (TMA) defi nes a clinicopathological syndrome consisting of intraluminal platelet thrombosis in the microvasculature and the presence of fragmented red blood cells and thrombocytopaenia in the peripheral blood, and may be seen in haemolytic uraemic syndrome (HUS)...

AIMS: 4-Iodo-2,5-dimethoxyamphetamine (DOI), 4-bromo-2,5-dimethoxyamphetamine (DOB), 4-bromo2,5-dimethoxymethamphetamine (MDOB), and 2,4,5-trimethoxyamphetamine (TMA-2) are designer drugs which have appeared on the illicit drug market. Meanwhile, DOB and TMA-2 have been scheduled in the German Controlled Substances Act. Because of the various possibilities of interactions between different drug...

Voltage-dependent Na conductance of rat myotubes was studied by patch recordings of single-channels. The patches were excised from the cell with the patch electrode, and the cytoplasmic surface was bathed in either CsF or tetramethylammonium (TMA)-F. Inward currents were examined from -20 to -50 mV. In this range Cs and TMA both appeared to be nearly impermeant, but TMA blocked the channel in a...

Thrombotic microangiopathy (TMA) is a severe complication of kidney transplantation that often causes graft failure. TMA may occur de novo, often triggered by immunosuppressive drugs and acute antibody-mediated rejection, or recur in patients with previous history of hemolytic uremic syndrome (HUS). Recurrent TMA is very rare in patients who had developed end-stage renal failure following HUS c...

In the setting of partially ordered metric spaces, using the notion of compatible mappings, we establish the existence and uniqueness of coupled common fixed points involving a (φ ,ψ )-contractive condition for mixed g-monotone operators. Our results extend and generalize the well-known results of Berinde (Nonlinear Anal. TMA 74:7347-7355, 2011; Nonlinear Anal. TMA 75:3218-3228, 2012) and weake...

Abstract Background and Aims Certain thrombotic microangiopathies (TMA) respond to inhibition of complement factor C5, which abrogates formation the membrane attack complex hence impairs host defense. Inhibition C5a receptor (C5aR) avoids this safety problem still controls autoimmune systemic vasculitis. We speculated that targeting C5aR could be sufficient also in TMA, e.g., related cholestero...