The goal of this paper is to lay a foundation for rigorous empirical software engineering. I do this by introducing several theories and their models. I first present an abstract theory TM about theories and models and related processes. I then apply TM to itself, yielding MTM, a theory and model about TM. These two theories provide a unified approach to design disciplines. I then provide 4 mod...

We have investigated how the transmembrane (TM) domain of a membrane protein is cotranslationally integrated into the endoplasmic reticulum. We demonstrate that the Sec61p channel allows the TM domain to bypass the barrier posed by the polar head groups of the lipid bilayer and come into contact with the hydrophobic interior of the membrane. Together with the TRAM protein, Sec61p provides a sit...

Tetrathiomolybdate (TM) is a potent nontoxic orally delivered copper complexing agent under development for the last several years for the treatment of Wilson's disease. It has been shown to block angiogenesis in primary and metastatic tumors. Therefore, the combination of cytotoxic radiotherapy (RT) and antiangiogenic TM could target both the existing tumor and the tumor microvasculature in a ...

Social media has become a major source for analyzing all aspects of daily life. Thanks to dedicated latent topic analysis methods such as the Ailment Topic Aspect Model (ATAM), public health can now be observed on Twitter. In this work, we are interested in monitoring people’s health over time. Recently, Temporal-LDA (TM–LDA) was proposed for efficiently modeling general-purpose topic transitio...

Primary open-angle glaucoma (POAG) with complex pathogenesis is one of the many major causes of blindness. It is widely accepted that the major cause of POAG is the dysregulation of the trabecular meshwork (TM), which regulates the resistance to aqueous humour outflow. Intraocular pressure is elevated with increasing outflow resistance in the conventional pathway, which consists of the TM and S...

Text mining (TM) has emerged as a definitive technique for knowledge acquisition from text. The TM process is based on several phases that prepare the text for mining, process the text, and analyze the results. Effective and efficient use of the combination of TM algorithms and techniques is a challenge. Most of the research is focused on developing new data structures, algorithms and methods t...

Rough set and fuzzy set are two frequently used approaches for modelling and reasoning about imperfect time intervals. In this paper, we focus on imperfect time intervals that can be modelled by rough sets and use an innovative graphic model [i.e. the triangular model (TM)] to represent this kind of imperfect time intervals. This work shows that TM is potentially advantageous in visualizing and...

The PhoQP two-component system is a signaling complex essential for bacterial virulence and cationic antimicrobial peptide resistance. PhoQ is the histidine kinase chemoreceptor of this tandem machine and assembles in a homodimer conformation spanning the bacterial inner membrane. Currently, a full understanding of the PhoQ signal transduction is hindered by the lack of a complete atomistic str...

Acute promyelocytic leukemia (APL) is characterized by the expansion of blasts that resemble morphologically promyelocytes and harbor a chromosomal translocation involving the retinoic acid receptor alpha (RARalpha) and the promyelocytic leukemia (PML) genes on chromosomes 17 and 15, respectively. The expression of the PML/RARalpha fusion gene is essential for APL genesis. In fact, transgenic m...

In order to better understand signal propagation in the ear, a time-domain model of the tympanic membrane (TM) and of the ossicular chain (OC) is derived for the cat. Ossicles are represented by a two-port network and the TM is discretized into a series of transmission lines, each one characterized by its own delay and reflection coefficient. Volume velocity samples are distributed along the ea...