This document presents TLS and how to make it secure enough as of 2014 Spring. Of course all the information given here will rot with time. Protocols known as secure will be cracked and will be replaced with better versions. Fortunately we will see that there are ways to assess the current security of your setup, but this explains why you may have to read further from this document to get the u...

BACKGROUND Catheter-related bloodstream infections (CRBSIs) are a significant cause of morbidity and mortality in critically ill patients, contributing to prolonged hospital stays and increased costs. Whether taurolidine lock solutions (TLS) are beneficial for the prevention of CRBSIs remains controversial. In this meta-analysis, we aim to assess the efficacy of TLS for preventing CRBSIs. MET...

Translesion DNA synthesis (TLS) by specialized DNA polymerases (Pols) is a conserved mechanism for tolerating replication blocking DNA lesions. The actions of TLS Pols are managed in part by ring-shaped sliding clamp proteins. In addition to catalyzing TLS, altered expression of TLS Pols impedes cellular growth. The goal of this study was to define the relationship between the physiological fun...

PURPOSE We examined whether exercise-induced lymphocytosis and lymphocytopenia are impaired with high-intensity training. METHODS Eight trained cyclists (VO(2max) = 64.2 ± 6.5 mL · kg(-1) · min(-1)) undertook 1 wk of normal-intensity training and a second week of high-intensity training. On day 7 of each week, participants performed a cycling task, consisting of 120 min of submaximal exercise...

Abstract Collecting metadata from Transport Layer Security (TLS) servers on a large scale allows to draw conclusions about their capabilities and configuration. This provides not only insights into the Internet but it enables use cases like detecting malicious Command Control (C &C) servers. However, active scanners can observe interpret behavior of TLS servers, underlying configuration imp...

We report ongoing work towards a verified reference implementation of TLS 1.3 in the F* programming language. Our code supports selected ciphersuites for all versions of TLS from 1.0 to 1.3. It is being developed on http://github.com/mitls as the next version of MITLS, written in F instead of F#. We intend to prove a strong, joint cryptographic security theorem for TLS 1.3 clients and servers, ...

Proliferating cell nuclear antigen (PCNA) encircles DNA as a ring-shaped homotrimer and, by tethering DNA polymerases to their template, PCNA serves as a critical replication factor. In contrast to high-fidelity DNA polymerases, the activation of low-fidelity translesion synthesis (TLS) DNA polymerases seems to require damage-inducible monoubiquitylation (Ub) of PCNA at lysine residue 164 (PCNA...

This document describes a Transport Model for the Simple Network Management Protocol (SNMP), that uses either the Transport Layer Security protocol or the Datagram Transport Layer Security (DTLS) protocol. The TLS and DTLS protocols provide authentication and privacy services for SNMP applications. This document describes how the TLS Transport Model (TLSTM) implements the needed features of a S...

PrimPol is a DNA damage tolerance enzyme possessing both translesion synthesis (TLS) and primase activities. To uncover its potential role in TLS-mediated IgVλ hypermutation and define its interplay with other TLS polymerases, PrimPol(-/-) and PrimPol(-/-)/Polη(-/-)/Polζ (-/-) gene knockouts were generated in avian cells. Loss of PrimPol had no significant impact on the rate of hypermutation or...