نتایج جستجو برای: tlr5
تعداد نتایج: 700 فیلتر نتایج به سال:
Pseudomonas aeruginosa is the principal cause of bacterial keratitis worldwide and overstimulation of the innate immune system by this organism is believed to contribute significantly to sight loss. In the current study, we have used primary human corneal fibroblast (hCF) cells as an ex vivo model of corneal infection to examine the role of P. aeruginosa flagellum and type three secretion syste...
The recognition of PAMPs by TLRs initiates the induction of inflammatory responses in the host cells through activation of signal transduction pathways mediated by transcription factor (nuclear factor-κB, NF-κB). Considering TLRs expressed in human cells TLR1, TLR2, TLR4, TLR5, and TLR6 are positioned near trans-membrane domains and are vital to the defense response of cells against external pa...
BACKGROUND Induction therapy can improve kidney transplantation (KTx) outcomes, but little is known about the mechanisms underlying its effects. METHODS The mRNA levels of T cell-related genes associated with tolerance or rejection (CD247, GZMB, PRF1, FOXP3, MAN1A1, TCAIM, and TLR5) and lymphocyte subpopulations were monitored prospectively in the peripheral blood of 60 kidney transplant reci...
BACKGROUND Melioidosis, caused by the flagellated bacterium Burkholderia pseudomallei, is a life-threatening and increasingly recognized emerging disease. Toll-like receptor (TLR) 5 is a germline-encoded pattern recognition receptor to bacterial flagellin. We evaluated the association of a nonsense TLR5 genetic variant that truncates the receptor with clinical outcomes and with immune responses...
The newborn gut undergoes rapid colonization by commensal microorganisms and possible exposure to pathogens. contribution of colostrum intake host protection is well known; however, limited research exists on the intestinal innate immunity corresponding during passive immune transfer period in ruminants. aim this study was investigate changes bacterial community expression genes encoding toll-l...
BACKGROUND Plasmodium vivax malaria (Pv-malaria) is still considered a neglected disease despite an alarming number of individuals being infected annually. Malaria pathogenesis occurs with the onset of the vector-parasite-host interaction through the binding of pathogen-associated molecular patterns (PAMPs) and receptors of innate immunity, such as toll-like receptors (TLRs). The triggering of ...
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