نتایج جستجو برای: tlr5

تعداد نتایج: 700  

2017
Maria del Mar Cendra Myron Christodoulides Parwez Hossain

Pseudomonas aeruginosa is the principal cause of bacterial keratitis worldwide and overstimulation of the innate immune system by this organism is believed to contribute significantly to sight loss. In the current study, we have used primary human corneal fibroblast (hCF) cells as an ex vivo model of corneal infection to examine the role of P. aeruginosa flagellum and type three secretion syste...

2013
V. Bueno O. Augusto Sant’Anna

The recognition of PAMPs by TLRs initiates the induction of inflammatory responses in the host cells through activation of signal transduction pathways mediated by transcription factor (nuclear factor-κB, NF-κB). Considering TLRs expressed in human cells TLR1, TLR2, TLR4, TLR5, and TLR6 are positioned near trans-membrane domains and are vital to the defense response of cells against external pa...

2015
Eva Krepsova Irena Tycova Alena Sekerkova Peter Wohlfahrt Petra Hruba Ilja Striz Birgit Sawitzki Ondrej Viklicky

BACKGROUND Induction therapy can improve kidney transplantation (KTx) outcomes, but little is known about the mechanisms underlying its effects. METHODS The mRNA levels of T cell-related genes associated with tolerance or rejection (CD247, GZMB, PRF1, FOXP3, MAN1A1, TCAIM, and TLR5) and lymphocyte subpopulations were monitored prospectively in the peripheral blood of 60 kidney transplant reci...

2017
Panjaporn Chaichana Narisara Chantratita Florian Brod Sirikamon Koosakulnirand Kemajittra Jenjaroen Suchintana Chumseng Manutsanun Sumonwiriya Mary N Burtnick Paul J Brett Prapit Teparrukkul Direk Limmathurotsakul Nicholas P J Day Susanna J Dunachie T Eoin West

BACKGROUND Melioidosis, caused by the flagellated bacterium Burkholderia pseudomallei, is a life-threatening and increasingly recognized emerging disease. Toll-like receptor (TLR) 5 is a germline-encoded pattern recognition receptor to bacterial flagellin. We evaluated the association of a nonsense TLR5 genetic variant that truncates the receptor with clinical outcomes and with immune responses...

Journal: :Journal of Clinical Investigation 2007

Journal: :Journal of Dairy Science 2021

The newborn gut undergoes rapid colonization by commensal microorganisms and possible exposure to pathogens. contribution of colostrum intake host protection is well known; however, limited research exists on the intestinal innate immunity corresponding during passive immune transfer period in ruminants. aim this study was investigate changes bacterial community expression genes encoding toll-l...

2017
Allyson Guimarães Costa Rajendranath Ramasawmy Hiochelson Najibe Santos Ibiapina Vanderson Souza Sampaio Lilyane Amorim Xábregas Larissa Wanderley Brasil Andréa Monteiro Tarragô Anne Cristine Gomes Almeida Andrea Kuehn Sheila Vitor-Silva Gisely Cardoso Melo André Machado Siqueira Wuelton Marcelo Monteiro Marcus Vinicius Guimarães Lacerda Adriana Malheiro

BACKGROUND Plasmodium vivax malaria (Pv-malaria) is still considered a neglected disease despite an alarming number of individuals being infected annually. Malaria pathogenesis occurs with the onset of the vector-parasite-host interaction through the binding of pathogen-associated molecular patterns (PAMPs) and receptors of innate immunity, such as toll-like receptors (TLRs). The triggering of ...

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