The death receptor CD95/Fas can be activated by immune cells to kill cancer cells. shRNAs and siRNAs derived from CD95 or CD95 ligand (CD95L) are highly toxic to most cancer cells. We recently found that these sh/siRNAs kill cancer cells in the absence of the target by targeting the 3'UTRs of critical survival genes through canonical RNAi. We have named this unique form of off-target effect DIS...

A disturbance accommodating controller (DAC) to reject wind speed perturbations is applied on a 5MW wind turbine mounted on a tension leg platform (TLP). Multi-blade coordinate (MBC) transformation is used to address the periodicity of the floating wind turbine system. A method to apply DAC after applying MBC transformation is developed and several implementation options are presented. Simulati...

PAX5 is a member of the PAX family of developmental transcription factors with an important role in B-cell development. Its expression in normal adult tissue is limited to the hemopoietic system, but it is aberrantly expressed in a number of solid cancers and leukemias where it functions as an oncogene. We therefore hypothesized that anti-PAX5 immune responses could be used to target a number o...

The IC industry continues to find ways to improve the ability to correlate the electrical failure signature of devices with the physical failure location using different techniques. The purpose of this work is to show that improved transmission line pulse (TLP) testing technique of ESD (ElectroStatic Discharge) protection structures can provide accurate identification of leakage current to bett...

High Performance Fortran is the emerging standard beyond Fortran 90 and is targeted for parallel machines. Although CRI is monitoring this standard closely, there is no HPF product currently available from CRI. There are two commercial offerings of HPF for the T3D, one from the Portland Group and the other from Applied Parallel Research. Both of these products work in conjunction with CRI’s exi...

Fortran D is a version of Fortran enhanced with data decomposition speciications. Case studies illustrate strengths and weaknesses of the prototype Fortran D compiler when compiling linear algebra codes and whole programs. Statement groups, execution conditions, inter-loop communication optimizations, multi-reductions, and array kills for replicated arrays are identiied as new compilation issue...

Antifreeze proteins (AFPs) similar to three pathogenesis-related proteins, a glucanase-like protein (GLP), a chitinase-like protein (CLP), and a thaumatin-like protein (TLP), accumulate during cold acclimation in winter rye (Secale cereale) leaves, where they are thought to modify the growth of intercellular ice during freezing. The objective of this study was to characterize the rye AFPs in th...

1. Abstract Tension Leg Platforms (TLPs), if designed properly, are the best oil and natural production facilities in the world. They are utilized globally by prominent oil companies such as Hess, Conoco Philips, and Shell. We have designed a prototype TLP with two novel features. First, our prototype structure, dubbed the Governor’s School of Engineering and Technology (GSET) TLP, is taller th...