the autism spectrum disorders (asds) are common neurodevelopmental disorders estimated to affect 1 in 88 children. asd is a complex condition, result of genetic, epigenetic and environmental factors. however, genetic comopnent seems to play an important role. the loss/gain of 1kb and more nucleotides, copy number variation (cnv), is the significant genetic factor in the etiology of asd. the cnv...

In vitro models that capture the complexity of in vivo tissue and organ behaviors in a scalable and easy-to-use format are desirable for drug discovery. To address this, we have developed a bioreactor that fosters maintenance of 3D tissue cultures under constant perfusion and we have integrated multiple bioreactors into an array in a multiwell plate format. All bioreactors are fluidically isola...

To simultaneously analyze mutations and expression levels of multiple genes on one detection platform, we proposed a method termed "multiplex ligation-dependent probe amplification-digital amplification coupled with hydrogel bead-array" (MLPA-DABA) and applied it to diagnose colorectal cancer (CRC). CRC cells and tissues were sampled to extract nucleic acid, perform MLPA with sequence-tagged pr...

Array comparative hybridization has been used successfully to identify genomic alterations in stillbirth material; however, high DNA quantity and quality requirements may limit its utility in some fetal samples. Molecular inversion probe (MIP) array analysis of FFPE stillbirth autopsy samples circumvents the challenges associated with karyotype and short-term fetal cell culture, requires limite...

BACKGROUND A major challenge in the field of neural interfaces is to overcome the problem of poor stability of neuronal recordings, which impedes long-term studies of individual neurons in the brain. Conceivably, unstable recordings reflect relative movements between electrode and tissue. To address this challenge, we have developed a new ultra-flexible electrode array and evaluated its perform...

a noninteracting quantum-dot arrays side coupled to a quantum wire is studied. transport through the quantum wire is investigated by using a noninteracting anderson tunneling hamiltonian. the conductance at zero temperature develops an oscillating band with resonances and antiresonances due to constructive and destructive interference in the ballistic channel, respectively. moreover, we have fo...

Pallister-Killian syndrome (PKS) is a rare multisystem disorder characterized by isochromosome 12p and tissue-limited mosaic tetrasomy 12p. In this study, we diagnosed three pediatric patients who were suspicious of having PKS using array-based comparative genomic hybridization (array CGH) and FISH analyses performed on peripheral lymphocytes. Patients 1 and 2 presented with craniofacial dysmor...

Abstract Purpose of Review Fibro-adipogenic progenitors were first characterized in 2010 and later found to contribute significantly muscle regeneration mediate degenerative changes following injury. These also have an influence on the rotator cuff muscle’s response chronic injury which is defined by fibrosis accompanied massive fatty degeneration. The purpose this review highlight progenitor c...

Wireless in-body bioelectronics offer powerful biosensing and therapeutic capabilities. Efficient robust antenna designs are required to ensure a reliable through-body link, increase data rates, reduce power budgets. This study proposes demonstrates pattern- frequency-reconfigurable capsule-conformal array that responds the challenges of next-generation bioelectronics. The comprises two mirrore...

This paper describes a method to fabricate a transplantable three-dimensional (3D) neuronal network using the neurospheroid network (NSN) on a polydimethylsiloxane (PDMS) microchamber array. We developed a technique, termed the “NSN-stamping method”, to transfer the NSN onto other substrates without any chemical treatment. Using this method, we demonstrate that different NSNs were stacked and f...