I Selsin BI.. Systemic effects of topical ophthalmic medications. South MedJ7 1983;76:349-58. 2 Hayes LP, Stewart CJ, Kim I, Mohr JA. Timolol side effects and inadvertent overdosing. JAmGeiatr Soc 1989;37:261-2. 3 Pringle SD, MacEwen CJ. Severe bradvcardia due to interaction of timolol eyedrops and verapamil. BrMedJ 1987;294:155-6. 4 Falbe WJ, Boyd DL. Homatropine-associated confusion in an eld...

A 70-year-old man with glaucoma was treated with eyedrops containing timolol maleate and brimonidine tartrate for >2 years. The patient presented with erythematous and oedematous pruritic lesions on both cheeks (Fig. 1a). Patch testing was performed with the Spanish Contact Dermatitis Research Group baseline series (TRUE Test®; Stallergenes Ibérica, Madrid, Spain; Brial Allergens GmbH,Greven, G...

Discussion. A significant increase in facility of outflow did not occur to account for the decrease in intraocular pressure. We conclude from this experiment that the mechanism of action for the ocular hypotensive effect of timolol is not by increasing the outflow of aqueous humor from the eye. We believe that it is most likely that timolol decreases the secretion of aqueous humor, and experime...

AIM To investigate respiratory and cardiovascular side effects in elderly people in the first 12 months after commencing topical beta antagonists. METHODS 40 patients (mean age 74 years) were recruited to a randomised, masked study. Spirometry, pulse, and blood pressure were recorded before, 1 month, and 12 months after starting topical therapy with either timolol 0.5% twice daily or betaxolo...

Recently, literature has suggested that Timolol gel 0.5% is a safe and effective treatment for pyogenic granuloma (PG) in children. We present the case of a 3 year-old girl with a PG in the left medial canthus, which was treated with Timolol and resolved after 6 months with no evidence of scarring. Citation: Del Pozzo-Magaña B, Lara-Corrales I (2014) Topical Timolol for pyogenic granuloma in a ...

An 8 month old boy on maintenance propranolol for paroxysmal supraventricular tachycardias presented with a depressed level of consciousness, bradycardia and hypotension, triggered by the accidental nasal administration of the ophthalmic β blocker timolol. Timolol eye drops are not licensed for use in children, and safety data has been derived mainly from adult studies. There is a theoretical p...

There are conflicting reports on the propensity of topical beta blockers to produce corneal anaesthesia. We measured corneal sensitivity thresholds quantitatively for 10 minutes following the administration of one drop of topical timolol maleate (0.5%), betaxolol hydrochloride (0.5%), or saline in 30 eyes of 18 normal subjects in a randomised, double-masked study. Most subjects had insignifican...

The outflow system was studied by light microscopy in nine human eyes that were treated with topical timolol maleate (0.5%) prior to enucleation for malignant melanoma of the choroid. The frequency of "giant vacuoles" in the lining endothelium of Schlemm's canal and the diameter of these structures was the same in a control group of eyes as in the timolol-treated series. There was no qualitativ...

In a double-masked, 3-month clinical study the ocular hypotensive effects of diacetyl nadolol (DAN), timolol, and nadolol were compared. When applied topically to the eyes of glaucomatous patients timolol 0.5% was found to be significantly more effective than DAN 2% in controlling IOP at 3 of 10 evaluation periods. Fewer patients, however, developed tolerance to DAN 2% than to timolol 0.5%. DAN...

BACKGROUND This study aimed to determine the frequency, nature, and impact of side effects associated with the use of brinzolamide-timolol suspension, a topical ocular antihypertensive preparation. METHODS A questionnaire was distributed to 76 consecutive patients attending the Sunderland Eye Infirmary Glaucoma Service who were using the brinzolamide-timolol suspension. The questions related ...