OBJECTIVES Effects of acute exposure to organophosphorous pesticides (OPs), chlorphenvinphos (CVP) or chlorphyriphos (CPF) on amphetamine (AMPH)- or scopolamine (SCOP)-induced open-field locomotion were compared in rats. MATERIALS AND METHODS CVP and CPF were administered intraperitoneally, both at doses resulting in about 50% inhibition of erythrocyte acetylcholinesterase (rbcAChE). The pest...

The development of automatic approaches for the comparison of protein sequences has become increasingly important. Methods that compare profiles allow for the use of information about whole protein families, resulting in more sensitive and accurate detection of distantly related sequences. In this contribution, we describe a thorough optimization and tests of a profile-to-profile alignment meth...

A new software fault tolerance scheme, called the Self-Configuring Optimistic Programming scheme, (SCOP), is proposed. It attempts to reduce the cost of fault tolerant software and to eliminate some inflexibilities and rigidities present in the existing software fault tolerance schemes. For obtaining these goals, it is structured in phases in order to produce acceptable results with the minimum...

MOTIVATION Remote homology detection between protein sequences is a central problem in computational biology. Discriminative methods involving support vector machines (SVMs) are currently the most effective methods for the problem of superfamily recognition in the Structural Classification Of Proteins (SCOP) database. The performance of SVMs depends critically on the kernel function used to qua...