This treatise is a compilation of papers presented at the Proceedings of the International Colloquium on Tumors of the Thyroid Gland, held in Marseilles. It was the purpose of such a meeting to assemble the world authorities in thyroid diseases regardless of, and most likely because of, their known prejudices. The study of thyroid tumors is exceedingly difficult. While any attempt to unravel th...

BACKGROUND Vascular endothelial growth factor (VEGF) is a key regulator of physiologic as well as pathologic angiogenesis. The response of VEGF to endothelial cell mitogenesis and survival, as well as angiogenesis and microvascular permeability, is mainly mediated through its receptor-2, VEGFR2 (kinase domain receptor or fetal liver kinase-1, KDR or Flk-1). This study aimed to detect the expres...

We described previously a thyroid phenotype for transgenic mice expressing an activated Ret oncogene driven from a human calcitonin promoter. Medullary thyroid carcinomas (MTC), a tumor of the thyroid parafollicular C cells, occur in this transgenic line with a pathology analogous to that seen in patients with multiple endocrine neoplasia type 2 (MEN2). When the transgene was introgressed onto ...

We described previously a thyroid phenotype for transgenic mice expressing an activated Ret oncogene driven from a human calcitonin promoter. Medullary thyroid carcinomas (MTC), a tumor of the thyroid parafollicular C cells, occur in this transgenic line with a pathology analogous to that seen in patients with multiple endocrine neoplasia type 2 (MEN2). When the transgene was introgressed onto ...

Destruction of the thyroid gland by I's' in mice is followed by the development of TSH (thyroid stimulating hormone)-secreting pituitary tumors (5, 11, 13). These tumors can at first be grafted only on mice similarly radiothyroidectomized and not on normal animals (5) ; thus, they are initially conditioned or dependent growths. The tumor cells gain autonomy in the course of passages, as mdi cat...

OBJECTIVES To examine the rates of incidence and fatality in cohorts of patients diagnosed with thyroid cancer from 1975 to 1999. METHODS This study uses National Cancer Institute's Surveillance, Epidemiology and End Results data and derives hazard functions in order to examine the fatality in thyroid cancer. RESULTS The study documents forms of rapidly evolving and fatal tumors as well as ...

The thyroid gland is a known but an unusual site for metastatic tumors from various primary sites. Despite the fact that it is one of the largest vascular organs in the body, clinical and surgical cases have given an incidence of 3% of secondary malignances of the organ. Nevertheless, thyroid metastases are not an exceptional finding at autopsy, they are encountered in 2% to 24% of the patients...

Abstract Introduction/Objective Introduction: Cadherin-16 (CDH16), also termed kidney specific cadherin (ksp-cadherin), is a membrane-associated glycoprotein with role in the embryonal development of tubules and thyroid. Downregulation CDH16 RNA was found papillary carcinomas Methods/Case Report Methods: A set tissue microarrays containing 14,978 samples from 149 different tumor types subtypes ...

Background: Noninvasive Follicular Thyroid Neoplasm (NIFTP), Well differantiated thyroid tumor with uncertain malignity potential (WDT-UMP), follicular (FT-UMP), and Hurtle cell neoplasia (HCN-UMP) have been included in the classification of tumors by WHO, incidence cancer increasing every passing year. There is no consensus regarding follow-up treatment processes these tumors. Our study aims t...