Background: Thyroid papillary carcinoma is the most common clinical thyroid malignancy. Autophagy is related to the occurrence and development of tumors. However, there is no report about the correlation between autophagy protein expression and biological characteristics of thyroid papillary carcinoma and lymph node metastasis. Therefore, the authors studied the relationship between autophagy p...

BACKGROUND Radioactive iodine as a treatment modality has been shown in several studies to be a safe and effective therapy for Graves disease. However, there is still no uniformity regarding optimal dosing method. The aim of this study is to compare the efficacy of calculated and fixed dosing of radioiodine for the treatment of Graves disease. METHODS A hundred twenty-two patients diagnosed w...

Thyroid hormones are intimately related to mood and behavior, as is vividly evident in the anxiety and agitation of hyperthyroidism and the lethargy of the hypothyroid state. Extremes of activity (augmented or reduced) seen in severe developmental disturbances are often target symptoms for medication, and triidothyronine (T3) has been used in the treatment of childhood psychoses with a benefici...

BACKGROUND Thyroid autoimmunity is more common in patients with rheumatic diseases than in healthy populations. The degree of association seems subject to influence from patients' geographical location. Here, we aimed to ascertain the prevalence of thyroid autoantibodies in a cohort of patients with systemic rheumatic disease and the degree of association between its presence and inflammatory a...

There have been recent advances in understanding of the local control of thyroid activity and metabolism, including deiodinase activity and thyroid hormone membrane transport. The goal of this review is to increase the understanding of the clinical relevance of cellular deiodinase activity. The physiologic significance of types 1, 2 and 3 deiodinase (D1, D2 and D3, respectively) on the intracel...

Introduction: Various radiopharmaceuticals, including 67Ga, 201Tl, and 99mTc-sestamibi have been used to differentiate benign from malignant thyroid nodules. 99mTc-Tetrofosmin, a lipophilic cationic radiotracer, and 99mTc-sestamibi have also been reported to accumulate in thyroid tumors. In this study, we evaluated the role of 99mTc-Tetrofosmin in the differentiation of malignant from ben...

I131 is a famous radio-iodine isotope in use for diagnosis and treatment of hyper functioning and cancerous thyroid gland. It is a nuclear reactor product; however nuclear reactor may be unavailable in some areas. Replacement by I-124 may be possible, another iodine isotope producible by cyclotron; a system more available than reactor. Here absorbed fraction of Gamma and Beta rays of...

I131 is a famous radio-iodine isotope in use for diagnosis and treatment of hyper functioning and cancerous thyroid gland. It is a nuclear reactor product; however nuclear reactor may be unavailable in some areas. Replacement by I-124 may be possible, another iodine isotope producible by cyclotron; a system more available than reactor. Here absorbed fraction of Gamma and Beta rays of...

the variations of glucose 6-phosphate dehydrogenase (g6pd) activity in different brain regions of normal, hypo- and hyperthyroid rats were investigated. hypo- and hyperthyrodism were experimentaly induced by administration of methimazol and liothyronine, respectively. in normal rats, midbrain had the minimum (70 mu/mg) and cerebral cortex the maximum (349 mu/mg) g6pd activity. hyperthyrodism in...

Previously, a number of workers have described preparations of thyroid tissue which catalyze the iodination of free or proteinbound tyrosine (l-7). It was demonstrated that the enzymatic activity was mitochondrial in location, and depending upon the method of preparation or assay, various metals and cofactors were implicated in the reaction. Serif and Kirkwood (1, 2) found that addition of cert...