A new high-throughput viscosimeter device was designed, built, and tested allowing measurement of the viscosity of 100 different solutions in a single experiment using the falling sphere approach. Using the corrected Stokes' law, viscosities obtained by the HT device were compared to viscosities of the same solutions obtained on a conventional viscosimeter and showed excellent correlation. The ...

Information retrieval is the process of finding relevant information in large corpora of documents based on user queries. Within the discipline there are a number of open research questions and areas. This thesis presents a systematic study into improving the speed of all aspects of an information retrieval system, without such improvements having an adverse effect on the effectiveness of that ...

Even though natural products has an excellent record as a source for new drugs, the advent of ultrahigh-throughput screening and large-scale combinatorial synthetic methods, has caused a decline in the use of natural products research in the pharmaceutical industry. This is due to the efficiency in generating and screening a high number of synthetic combinatorial compounds; whereas traditional ...

Background: The potential applications of a simplified method of somatic cell nuclear transfer (SCNT) that is improved in both efficiency and throughput is considerable. Technically, a major step of SCNT is to produce large pools of enucleated oocytes (cytoplasts) efficiently, a process that requires considerable micromanipulation skill and expensive equipment. Here, we have devel oped an efficient...

If industry visionaries are correct, our lives will soon be full of sensors, connected together in loose conglomerations via wireless networks, each monitoring and collecting data about the environment at large. These sensors behave very differently from traditional database sources: they have intermittent connectivity, are limited by severe power constraints, and typically sample periodically ...

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Absti-ucfThis paper investigates the performance of directsequence spread-spectrum packet radio networks in the presence of the near/far problem. It is found that the maximum throughput of the network suffers degradation due to the near/ far problem. However, analysis also shows that, under high traffic conditions, a network with the near/far problem delivers higher throughput than another with...

This technical note describes the ontology-based meta-analysis framework developed by Illumina, which enables analysis of global high-throughput geneand sequence-centric data sets. Queries enabled within this meta-analysis framework include the user’s own sets of data, as well as genes, single-nucleotide variants (SNVs), sequence regions, or biogroups (i.e., pathways) of interest. This meta-ana...

OF THE DISSERTATION xiv 1 Data structures and compression algorithms for HTS technologies 1 1.