Cephalosporins are ┚lactam antibiotics. In cephalosporin C, four membered ┚lactam ring (which is mainly responsible for the activity) is fused with six membered dihydrothiazine ring to form the basic nucleus, 7-aminocephalosporanic acid (7-ACA) and to which ┙aminoadipic acid side chain is attached through an amide bond (Fig 1). (Mandell and Sande,1991)Although cephalosporin was found to be acti...

Antimicrobial resistance continues to increase globally and treatment of difficult-to-treat (DTT) infections, mostly associated with carbapenem-resistant (CR) Pseudomonas aeruginosa, CR Acinetobacter baumannii, CR- third-generation-cephalosporins-resistant Enterobacterales remains a challenge for the clinician. The recent approval cefiderocol has broaden armamentarium patients DTT infections. C...

PURPOSE To evaluate the effectiveness of new management policies on the incidence of invasive Candida infections. METHODS This observational study involved a retrospective analysis of the patients' medical records. In total, 99 very low birth weight infants, who were admitted to the neonatal intensive care unit at Ajou University Hospital from January 2010 to December 2011, were enrolled for ...

OBJECTIVE To study the in-vitro antimicrobial activity of Cefpirome: A new fourth generation Cephalosporin in comparison with other agents against clinically significant Gram-negative and Gram-positive bacteria. SETTING A multi-center in-vitro study was conducted in 13 centers. MATERIALS AND METHODS Bacterial isolates--A total of 1300 isolates were collected from different clinical laborato...