N,N'-((dodecane-1,12-diylbis(azanediyl))bis(carbonothioyl))bis(4-nitrobenzamide) 5 and N,N'-((dodecane-1,12-diylbis(azanediyl))bis(carbonothioyl))bis(3-nitrobenzamide) 6 as bis acyl thiourea derivatives were synthesized their molecular structures characterized using 1H NMR, 13C COSY, DEPT, HMQC, FT-IR, HRMS techniques. The acid dissociation constants (pKa) of the bis-acyl 5, determined potentio...

Article history: Received on: 06/02/2017 Accepted on: 30/03/2017 Available online: 30/06/2017 Objectives: The present research work is designed to synthesize some new series of quinazoline-4-one/4-thione derivatives by modifying the structures retaining the fundamental structural features for the biological activity and screened for their anti-microbial, analgesic and anti-inflammatory properti...

A novel series of acyclic nucleosides 2-5 and 13a-c were synthesized by utilizing 4-phenyl-6(naphthalen-2-yl)-2-oxo-1,2-dihydropridine-3-carbonitrile (1) as a key starting material. Chlorination of 1 yielded the chloro analogue 6 that was allowed to react with urea, thiourea, thiosemicarbazide and alicyclic secondary amines to produce the corresponding derivatives 7a-c and 11a-c. Further conden...