نتایج جستجو برای: thiosemicarbazone
تعداد نتایج: 917 فیلتر نتایج به سال:
Thiosemicarbazones and their metal complexes are compounds that possess antitumor, antibacterial, antifungal and antiviral properties. For the foremost majority of cases the activity of the ligand is greatly enhanced by the presence of a metal ion. The most relevant papers recently published are reviewed with an attempt to find a relationship between common structural features and activity.
REFERENCES 1. W. S. DAVIDSON: .. Evaluation of New Treatments" Lep. Rev. XXIV, 139, 1953. 2. E. GRUNBERG and R. J. SCHNITZER: .. Antagonism of Isoniazid and Strepto mycin in Experimental Infection of Mice with M. Tuberculosis H37Rv." America// Rev. of Tubermlosis, Vol. 68. 277. 1953. 3. W. SZYBALSKI and V. BRYSON: .. Conditional Antagonism between Isoniazid and other Antibacterial Agents." Ibi...
Thiosemicarbazone complexes possess structural diversity and variable bonding patterns potential biological implications ion sensing abilities. The ability of the transition metals to acquire different geometries like octahedral, square planar tetrahedral in coordination environments has encouraged researchers explore chemistry thiosemicarbazone which can also vary upon changing aldehydes keton...
Lack of p53 expression or expression of mutant p53 is common in human cancers and is associated with increased tumor growth and resistance to therapies. Significant efforts toward pharmaceutical reactivation of defective p53 by small molecules are therefore underway, targeting the different means that inactivate p53. Indeed, reactivated p53 can lead to tumor destruction. A recent paper in Cance...
This article reports data on four carbazones of piperitone: semicarbazone 1, thiosemicarbazone 2, 4-phenyl semicarbazone 3 and 4-phenyl thiosemicarbazone 4 prepared directly in situ from essential oil of Cymbopogon schoenantus, whose GC-FID and GC-MS analysis revealed piperitone as major component (68.20%). The structures of hemi-synthesized compounds were confirmed by high throughput IR, MS, 1...
Cancer is one of the leading causes of death worldwide and there is an increasing need for novel anti-tumor therapeutics with greater selectivity and potency. A new strategy in the treatment of cancer has focused on targeting an essential cell metabolite, iron (Fe). Iron is vital for cell growth and metabolism, forming a crucial component of the active site of ribonucleotide reductase (RR), the...
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