The (Ca + , Mg 2+ ) ATPase activity, the membrane fluidity, the total phospholipid contents and the individual phospholipids, phophatidylcholine (PC), lysophosphatidylcholine (LPC), phosphatidylethanolamine (PE), phosphotidylinositol (PI) and sphingomyelin (SM) were determined in red blood cell membranes of 54 patients with essential hypertension (31 treated, THP, and 14 untreated, UHP) and com...

HONDA, NISHIO, CHXKARA AIZAWA, AND YAWARA YOSHITOSHL Postocclusiue reactive hyferemia in the rabbit kidney. Am. J. Phvsiol. 215(l): 190-196. 1968.-Postocclusive hyperemia wa$ studied in the intact rabbit kidney. Characteristically, two phases of hyperemia were revealed after release of thp: arterial occlusion: an initial phase of overshoot of flow and a succeeding decrement below the preocclusi...

Thp American/ournal o/Occupa/iollal Tberapy j oint stiffness and soft tissue contractu res of the fingers are common problems treated by the occupational therapist specializing in hand therapy. It is Widely accepted that dynamic splinting in combination with range-of-motion exercises is the most effective way of managing these problems. The rationale, prinCiples, and objectives of dynamic splin...

The human CD34 surface antigen is selectively expressed on stemlprogenitor cells within the hematopoietic system. Because CD34 expression is tightly linked to the immature status of hematopoietic cells, with expression being rapidly lost as hematopoietic cells mature and differentiate, an examination of its regulation may provide important insights into the molecular control of blood cell devel...

Mice provide material for studies of Y-chromosomal and autosomal sequences involved in sex determination. Eicher and coworkers have identified four subregions in the mouse Y chromosome, one of which corresponds to the Sxr fragment. This fragment demonstrates that only a small portion of the Y is necessary for male sex determination. The mouse Y chromosome also shows variants: the BALB/cWt Y chr...

The aim of this study was as part of a baseline assessment in PMTCT in the traditional health sector: a) to determine the views of women who have used the services of traditional practitioners before, during and/or after pregnancy, and b) to conduct formative research with traditional health practitioners (THPs), i.e. herbalists, diviners and traditional birth attendants (TBAs) on HIV, pregnanc...

Accumulating evidence suggest a reciprocal interaction between neurosteroids, especially 5alpha-pregnan-3alpha-ol,20-one (3alpha,5alpha-THP, allopregnanolone), and the serotonergic (5-HT) system. Both 5-HT and neurosteroids seem to play an important role in the pathophysiology of major depression. We have previously shown that a 7-d treatment with 3alpha,5alpha-THP drastically increases the spo...

Intraarterial chemotherapy with Adriamycin (ADM) has shown limited advantages over i.v. administration, with no reduction in systemic toxicities and modest decrease in peripheral plasma levels. In an effort to improve the selectivity of i.a. anthracycline chemotherapy, we compared pirarubicin (4'-O-tetrahydropyranyladriamycin, THP) and ADM in the surgically implanted VX2 rabbit tumor model. Bot...

Ligand pharmacology of histamine H(3)-receptors is species-dependent. In previous studies, two amino acids in transmembrane domain 3 (TM III) were shown to play a significant role. In this study, we characterized human and rat histamine H(3)-receptors (hH(3)R and rH(3)R, respectively), co-expressed with mammalian G proteins in Sf9 insect cell membranes. We compared a series of imidazole-contain...

BACKGROUND Traditional health practitioners (THPs) have been identified as a key local resource in the fight against human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) in South Africa. However, their approaches to the treatment of people living with HIV (PLHIV) have been met with scepticism by some biomedical practitioners amid increasing access to antiretroviral therap...