The first study on the reaction of C(+)-C-Se(-) 1,3-dipoles with electron-deficient alkenes and alkyne is reported. 2-Arylselenocarbamoylthiazolium inner salts, the unique thiazole carbene-derived C(+)-C-Se(-) 1,3-dipoles, reacted efficiently with methoxycarbonylallenes or dimethyl acetylenedicarboxylate to produce dihydroselenophenes or selenopheno[2,3-b]pyrazines, respectively, in high yields...

A new and efficient approach to benzocycles from cyclopropene derivatives is described. Deprotection by organolithiums and subsequent ring-opening cyclization of the related 2-cyclopropenyl phenyl or benzyl acetates generated benzofurans and isochromenes in one pot.

Chiral ruthenium(II)-salen complexes [RuII(salen)(PPh3)2] catalyse asymmetric aziridination of alkenes with up to 83% ees, asymmetric amidation of silyl enol ethers with up to 97% ees, and allylic amidation of cholesteryl acetates with good regioselectivity.

Tandem rhodium-catalyzed oxidative allylation and annulation of acetanilides with allyl acetate to afford the corresponding indoles are described. In addition, the site-selective C2 allylation, crotylation and prenylation of indoles using allylic acetates under rhodium catalysis are reported.

We have designed and synthesized novel bis-thiazole derivative. A 4-[bis(thiazol-2-ylamino)methyl]phenol was efficiently prepared in 71% yield by the reaction of 2-aminothiazole with 4-hydroxybenzaldehyde ethanol for 24 h. The structure newly obtained compound characterized 1H, 13C NMR mass spectrometry. Bis-thiazole derivative exhibits high tyrosinase inhibitory activity an IC50 value 29.71 μM...

This research study describes recent advances in understanding the effects of addition organic acids, such as acetic, lactic, citric and phytic on process plasma electrolytic oxidation (PEO) Ti using an alkaline bath. As developed over workpiece is central to determine particular morphological structural features growing oxide, focus then inter-relationships between electrolyte resultant regime...

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The structure-directing role of a variety noncovalent interactions in the solid state pyrazolyl-thiazole derivatives has been analyzed energetically using DFT calculations and by means Hirshfeld surface analysis.

The design, synthesis, and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitors are described. In continuing our program aim to search for potent CDK4 inhibitors, the introduction of a thiazole group at the hydrazone part has led to marked enhancement of chemical stability. Furthermore, by focusing on the optimization at the C-4' pos...

Thiazoles and thiazolyl-pyrazole derivatives have been efficiently synthesized under neat reaction conditions in excellent yields. Condensation of 3-(2-bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one (1), thiosemicarbazide (2) and various carbonyl compounds (3 & 5) gave corresponding thiazole (4) and thiazolylpyrazole derivatives (6) in excellent yields by using Hantzsch-Thiazole synthesis. The ...