Vitamine B1 thiamine is an essential component for glucose metabolism and energy production. The disulfide derivative, tetrahydrofurfuryl (TTFD), more absorbent compared to readily-available water-soluble salts since it does not require the rate-limiting transport system required absorption. However, detailed pharmacokinetics of TTFD under normal pathological conditions were clarified yet. Rece...

Bioassays of tissue extracts show that high (500-1000 mug/liter) kinetin concentrations which permit growth of tobacco callus cultures on media without added thiamine activate the biosynthesis of this vitamin by the tissues. Although the tissue concentration of thiamine may fall appreciably, it is maintained at a level adequate for survival and slow growth of the cultures, and there is a large ...

BACKGROUND The provision of high doses of thiamine may prevent thiamine deficiency in the post-partum period of displaced persons. METHODOLOGY/PRINCIPAL FINDINGS The study aimed to evaluate a supplementation regimen of thiamine mononitrate (100 mg daily) at the antenatal clinics in Maela refugee camp. Women were enrolled during antenatal care and followed after delivery. Samples were collecte...

In previous investigations of the metabolism of thiamine by leukocytes (7, 1), abnormally high contents of the vitamin were found in leukemic cells. The probable explanation for this abnormality was shown to be an impaired utilization of the vitamin and not its increased ingestion, the faulty excretion, or the apparent youth of the cells involved. No explanation for the impaired utilization was...

In the literature, a deficiency of magnesium or vitamin B1 in alcoholics is considered of etiologic importance in the development of delirium tremens or alcoholic encephalopathy (AE). As AE are comprised mnestic disorders, so severe as to lead to social invalidation, Korsakoff syndrome and dementia. Upon admission, the plasma concentrations of magnesium and vitamin B1 were determined in cases w...

Because pyrithiamine (neopyrithiamine)’ calls forth in higher animals many of the characteristic signs of thiamine deficiency (2), and because these manifestations may be prevented or corrected in a competitive fashion by the vitamin, the belief has arisen that the pharmacological properties of this analogue of the vitamin are due to its ability to interfere with the metabolic utilization of th...

BACKGROUND Vitamins involved in one-carbon metabolism are hypothesized to influence breast cancer (BC) risk. However, epidemiologic studies that examined associations between B vitamin intake and BC risk have provided inconsistent results. We prospectively examined, in the Italian ORDET cohort, whether B vitamin consumption was associated with risk of BC and BC subtypes. METHODS After a mean ...

introduction: immune system is involved in the etiology and pathophysiology of inflammation and vitamins are important sources of substances inducing nonspecific immunomodulatory effects. given the proinflammatory role of cytokines in the inflammation and pain induction, this study aimed to assess the effects of long-term administration of vitamin b1 on the proinflammatory cytokines, edema, and...

Sea cucumbers, belonging to the class Holothuroidea, are marine invertebrates, habitually found in the benthic areas and deep seas across the world. They have high commercial value coupled with increasing global production and trade. Sea cucumbers, informally named as bêche-de-mer, or gamat, have long been used for food and folk medicine in the communities of Asia and Middle East. Nutritionally...