نتایج جستجو برای: therapy resistance
تعداد نتایج: 996157 فیلتر نتایج به سال:
An international expert panel was convened to deliberate the management of azole-resistant aspergillosis. In culture-positive cases, in vitro susceptibility testing should always be performed if antifungal therapy is intended. Different patterns of resistance are seen, with multi-azole and pan-azole resistance more common than resistance to a single triazole. In confirmed invasive pulmonary asp...
Antineoplastic drug resistance represents a specialized case of drug tolerance since cells most responsive to therapy are destroyed. Clinically, drug resistance may be observed at the onset of therapy or is acquired later by a tumor cell population over time due to a combination of spontaneous genetic mutations and selection by cytotoxic chemotherapy. Numerous mechanisms of drug resistance have...
Currently available antiviral therapies specifically target viral replication by blocking reverse transcription with orally given nucleos(t)ide analogues and are able to specifically suppress viral replication. The unique replication strategy of hepatitis B virus (HBV), however, allows long-term persistence of the viral genome within infected hepatocytes in spite of successful therapy. Thus, an...
Purpose: Antiangiogenic therapy is effective in blocking vascular permeability, inhibiting vascular proliferation, and slowing tumor growth, but studies in multiple cancer types have shown that tumors eventually acquire resistance to blockade of blood vessel growth. Currently, the mechanisms by which this resistance occurs are not well understood. Experimental Design: In this study, we evaluate...
Previous studies indicate that breast cancer cells with high aldehyde dehydrogenase (ALDH) activity and CD44 expression (ALDHhiCD44⁺) contribute to metastasis and therapy resistance, and that ALDH1 correlates with poor outcome in breast cancer patients. The current study hypothesized that ALDH1 functionally contributes to breast cancer metastatic behavior and therapy resistance. Expression of A...
background: helicobacter pylori (h. pylori) resistance to antibiotics has become a global problem and is an important factor in determining the outcome of treatment of infected patients. the purpose of this study was to determine the h. pylori resistance to clarithromycin, metronidazole, and amoxicillin in gastrointestinal disorders patients. materials and methods: in this study, a total of 260...
conclusions our experimental and in silico findings may provide new insight in the complex molecular pathways of drug resistance and also could assist design an efficient therapeutic strategy for aspergillosis treatment. results four out of five isolates revealed cyp51a and mdr1 mrna overexpression. interestingly, the isolate, which was negative for cyp51a and mdr1 mrna expression showed a high...
pcos (polycystic ovarian syndrome) is associated with insulin resistance, obesity and disorders of lipid metabolism as well as infertility. fenugreek seeds extract is successfully used in lowering blood glucose. metformin has also the same effect but in a different way. the aim of this study was the assessment of fenugreek effects on insulin resistance in women with pcos.this was a prospective ...
Abstract Background and Objective: Staphylococcus aureus is an important opportunistic pathogen causing a wide range of infections in human .Most clinical isolates of S.aureus are resistant to a number of antibiotics. For appropriate antimicrobial therapy, this study was conducted to determine antibacterial drug resistance patterns of S.aureus isolates obtained from different clinical samp...
Human immunodeficiency virus type 1 (HIV-1) strains dually resistant to zidovudine and lamivudine (3TC) may arise during zidovudine-3TC combination therapy. The objective of this cross-sectional study (n = 43 patients) was to test the association between therapy response (clinical and immunologic) to zidovudine-3TC and the level of phenotypic zidovudine resistance and zidovudine resistance-asso...
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