In 2 individual cases of canine mast cell tumors, we identified 2 novel c-KIT mutations in exon 11: a 9-base pair (bp) deletion (c.1663-1671del) and a point mutation (c.1676T>A). The 9-bp deletion mutation caused a loss of 3 amino acids, corresponding to p.Gln555_Lys557del, and the point mutation resulted in the substitution of valine by aspartic acid (p.Val559Asp) in the juxtamembrane domain o...

The influence of halogen atom substitution (Br and I), in different amounts and positions in an aza-BODIPY skeleton, on the photophysical properties of some aza-BODIPY derivatives has been investigated by using density functional theory and its time-dependent extension. The heavy atom effect on excitation energies, singlet-triplet energy gaps and spin-orbit matrix elements has been considered. ...

PROLOGUE This lecture material is covered in one and one-half fiftyminute lecture periods. The primary objectives of the lecture are to: (i) review interpatient and intrapatient pharmacokinetic variability; (ii) introduce the concepts of therapeutic equivalence and bioequivalence; (iii) introduce the current FDA standards on bioequivalence; (iv) introduce the basic approach of bioequivalency te...

Neural stem cell transplantation has demonstrated its therapeutic potential in many neurological disorders. The long-thought prime mechanism of action was the replacement of cells lost to injury or neuro degeneration. Now, more and more evidence has provided insight into other bystander mechanisms through which these cell grafts could bring about a functional and structural restorative benefit....

Heparin is an important therapeutic agent for the prophylaxis and treatment of thrombosis. Although effective, heparin can cause, among other adverse effects, bleeding and thrombocytopenia, being obtained from bovine lungs and porcine intestines, causing concern about contamination with pathogenic animal agents. This study aimed at reviewing the literature on the relationship between the sulfat...

Regarding the nutritional value and availability of acorns in west and southwest of Iran, the effects of partial substitution of wheat flour with acorn flour was investigated. Wheat flour was replaced by treated acorn flour in the formulation of sponge cake and the quality characteristics were evaluated. Density of cakes was increased with increasing the acorn flour. As the substitution degree ...

In this paper we develop an inventory model, to determine the optimal ordering quantities, for a set of two substitutable deteriorating items. In this inventory model the inventory level of both items depleted due to demands and deterioration and when an item is out of stock, its demands are partially fulfilled by the other item and all unsatisfied demand is lost. Each substituted item incurs a...

conclusions a modified tool to assess methadone treatment response serves to identify patients at high-risk for relapse at a minimal cost, as well as evaluate the relevant physical and psycho-social domains affecting opioid-dependent patients. the great will serve as a useful adjunct to regular clinical assessments, allowing clinicians and researchers to properly assess opioid addiction patient...

results the mean qtc at baseline (pre-methadone) was 426 ± 34 msec and after being on methadone for an average of 8.72 ± 4.50 years was significantly higher at 450 ± 35 msec. no significant relationships were found between qtc prolongation and risk factors except for calcium. the methadone dosage was significantly higher in veterans with a qtc change above the mean change of ≥ 24 msec (88.48 ± ...