The unicellular green microalga Desmodesmus sp. S1 can produce more than 50% total lipid of cell dry weight under high light and nitrogen-limitation conditions. After irradiation by heavy (12)C(6+) ion beam of 10, 30, 60, 90 or 120 Gy, followed by screening of resulting mutants on 24-well microplates, more than 500 mutants were obtained. One of those, named D90G-19, exhibited lipid productivity...

Siemens AG, Healthcare Sector, Imaging, Particle Therapy, Hofmannstr. 26, 91052 Erlangen, Germany Ruprecht-Karls-Universität Heidelberg, Faculty of Physics and Astronomy, Im Neuenheimer Feld 227, 69120 Heidelberg, Germany Heidelberg Ion Therapy Center and Department of Radiation Oncology, Im Neuenheimer Feld 450, 69120 Heidelberg, Germany Present address: Department of Radiation Oncology, Unive...

Atomically ordered bimetal interfaces typically develop in near-equilibrium epitaxial growth (bottom-up processing) of nanolayered composite films and have been considered responsible for a number of intriguing material properties. Here, we discover that interfaces of such atomic level order can also emerge ubiquitously in large-scale layered nanocomposites fabricated by extreme strain (top dow...

Only target-conformal treatment allows one to exploit the advantages of ion beams (the increased dose and high biological efficiency at the end of the particle range) to a maximum extent. Up to now, target-conformal treatments such as spot scanning or intensity-controlled raster scanning have used fast magnetic lateral deflection in one or two directions perpendicular to the beam axis and a slo...

Mass spectrometry (MS) has become a powerful technology in the discovery and development of protein therapeutics in the biopharmaceutical industry. This review article describes recent developments and future trends in the characterization of protein therapeutics using MS. We discuss top-down MS for the characterization of protein modifications, hydrogen/deuterium exchange MS and ion mobility M...

According to statistics, early in the 20th century, the proportion of positive and negative air ions on the earth is 1 : 1.2. However, after more than one century, the equilibrium state of the proportion had an obvious change, which the proportion of positive and negative air ions became 1.2 : 1, leading to a surrounding of positive air ions in human living environment. Therefore, it is urgent ...

The long-range energy deposition by heavy-ion beams makes new shock wave experiments possible in the laboratory. We have investigated a situation that is of relevance to supernova dynamics in astrophysics, where a shock wave is irradiated by a flux of neutrinos depositing energy throughout the shock wave and surrounding matter, thus changing the behavior of the running shock. We have carried ou...

Several investigators (1, 2) have shown that when horse serum is denatured a change in the relative distribution of electrophoretic components occurs. Van der Scheer, Wyckoff, and Clarke (1) found that heating of serum at 65” resulted in the formation of a single component, with the disappearance of the albumin and globulin peaks of the serum. This was confirmed by Davis, Hollaender, and Greens...

The relationship between the electrical properties and structure evolution of single layer graphene was studied by gradually introducing the gallium ion irradiation. Raman spectrums show a structural transition from nano-crystalline graphene to amorphous carbon as escalating the degree of disorder of the graphene sample, which is in correspondence with the electrical transition from a Boltzmann...

The fabrication of an ion-exchanged waveguide beam deflector containing a photowritten grating is described. The planar waveguide was fabricated by thermal K(+) exchange in a borosilicate glass. The grating was written by photobleaching an absorption defect centered at 330 am, which was created by gamma-ray irradiation of the glass. The bleaching was accomplished with the 351-nm line from an ar...