Aminoglycoside antibiotics are used in the treatment of infections caused by Gram-negative bacteria, and are often dispensed only in severe cases due to their adverse side effects. Patients undergoing treatment with these antibiotics are therefore commonly subjected to therapeutic drug monitoring (TDM) to ensure a safe and effective personalised dosage. The ability to detect these antibiotics i...

Colchicine (COL) reduces the frequency of attacks in Familial Mediterranean Fever (FMF) patients and is effective preventing arresting renal amyloidosis most patients. COL has a narrow therapeutic window. The blood concentration to achieve effects can be determined by Therapeutic Drug Monitoring (TDM). However, use selective sensitive analytical methods necessary for achieving success with TDM....

Sirolimus is a potent immunosuppressive agent administered as prophylactic agent to prevent rejection after organ transplantation. Sirolimus must be used within a narrow therapeutic window. Due to inter- and intra-variability, sirolimus blood concentrations may be affected, therefore, there is no possibility of predicting the sirolimus blood concentrations based on the dose patients received. T...

Mass spectrometry-based quantitative analysis and biomarker discovery using metabolomics approach represent one of the major platforms in clinical fields including for the prognosis or diagnosis, assessment of severity and response to therapy in a number of clinical disease states as well as therapeutic drug monitoring (TDM). This review first summarizes our mass spectrometry-based research str...

Although tuberculosis is largely a curable disease, it remains a major cause of morbidity and mortality worldwide. Although the standard 6-month treatment regimen is highly effective for drug-susceptible tuberculosis, the use of multiple drugs over long periods of time can cause frequent adverse drug reactions. In addition, some patients with drug-susceptible tuberculosis do not respond adequat...

Digoxin was developed as a novel medication for the treatment of heart failure and atrial fibrillation (AF) 200 years ago. This investigation began with PubMed Google Scholar search various papers using terms digoxin safety efficacy, in failure, fibrillation. should be administered at dose 0.5–0.7 ng/mL individuals reduced ejection fraction. to decrease hospital readmissions, although SDC, crea...

Molecular targeted drugs (MTDs), such as tyrosine kinase inhibitors, have been actively developed and widely used in recent years due to their high selectivity therapeutic efficacy compared conventional cytotoxic chemotherapeutic agents. Bioanalysis of MTDs for drug monitoring (TDM) is performed by many medical clinical laboratories, the implementation TDM can lead better control tumor progress...