Introduction. ?Grey zone Lymphoma?? is associated with various entities. The last published classification of lymphoproliferative neoplasms includes mediastinal grey lymphoma. Precise diagnostic criteria are insufficient and establishing a diagnosis as complex deciding on treatment options. In this article pathologist hematologist discuss issues topic through case presentation literature review...

Introduction and purpose: Premature Ovarian Insufficiency (POI) is a rare but serious disease diagnosed in about 1% of women before the age 40. It characterized by hypoestrogenism an increase level follicle-stimulating hormone, which associated with menstrual disorders, pregnancy failures reduced quality life. The main causes POI include genetic background autoimmune abnormalities, as well incr...