background: despite the impressive results obtained with imatinib, inadequate response or resistance are observed in certain patients. it is known that imatinib is a substrate of a multidrug resistance gene (mdr1). thus, interindividual genetic differences linked to single nucleotide polymorphisms in mdr1 may influence the metabolism of imatinib. the present study has aimed to examine the impac...

The multidrug resistance 1 gene (MDR1) is an important candidate gene for influencing susceptibility to hepatocellular carcinoma (HCC). The objective of the present study was to evaluate the association of MDR1 polymorphisms with the risk of HCC in the Chinese Han population. A total of 353 HCC patients and 335 healthy subjects were enrolled in the study. Polymerase chain reaction-restriction f...

OBJECTIVE Many studies have focused on the association between the ABCB1 3435C>T polymorphism and colorectal cancer (CRC) risk. However, the results were conflicting. The aim of this meta-analysis is to evaluate the precise association between this polymorphism and CRC risk. METHODS We formally reviewed the literature at Pubmed, EMBASE and the Cochrane Library with the key words as follows: A...