OBJECTIVES Alpha thalassaemia is wide spread in Malaysia and is a public health problem. This study aimed to describe the carrier frequencies of α‒thalassaemia and its distribution among major ethnic groups in three states of Malaysia. METHODS Educational forums were organised and study was explained to students from three schools. Students were invited to take part in the screening with pare...

BACKGROUND Performance of the left ventricle during exercise stress in thalassaemia patients is uncertain. We aimed to explore the phenomenon of dynamic dyssynchrony and assess contractile reserve in patients with beta-thalassaemia major and determine their relationships with myocardial iron load. METHODS AND RESULTS Thirty-two thalassaemia patients (16 males), aged 26.8 ± 6.9 years, without ...

OBJECTIVE In Israel (population 5.7 million) there are around 200 known living subjects with thalassaemia major, of whom around 80% are from the northern district. This study aims at examining the costs and benefits of a national screening programme to prevent thalassaemia in Israel. MEASUREMENTS AND MAIN RESULTS The lifetime healthcare costs of caring for a person born with thalassaemia majo...