In the crystal structure of the title compound, C(17)H(21)N(3)O(2)·2H(2)O, water mol-ecules are mutually O-H⋯O hydrogen bonded and form infinite chains propagating along the b axis. Neighboring chains are linked by the quinazoline mol-ecules by means of O-H⋯O=C hydrogen bonds, forming a two-dimensional network.

We report two brothers, aged 2k and 4i, with similar features, namely developmental delay, short stature, and small delicate facies. Chromosome analysis revealed a pericentric inversion of chromosome 11 in one boy and a normal karyotype in the other. The father was shown to be the carrier of this pericentric inversion. Two brothers with mental retardation, particularly in the area of speech dev...

17β-hydroxyestra-4,9,11-trien-3-one (Trenbolone) Exhibits Tissue Selective Anabolic 1 Activity: Effects on Muscle, Bone, Adiposity, Hemoglobin, and Prostate 2 3 Joshua F. Yarrow, Christine F. Conover, Sean C. McCoy, Judyta A. Lipinska, Cesar A. 4 Santillana, John M. Hance, Darryl F. Cannady, Tisha D. VanPelt, Joshua Sanchez, Bryan P. 5 Conrad, Jennifer E. Pingel, Thomas J. Wronski, and Stephen ...

In the xanthenone system of the title compound, C23H20O4, the pyran ring has a maximum deviation of 0.111 (1) Å from planarity and the outer cyclo-hexene ring exhibits a puckered conformation. The three methyl-ene C atoms of the cyclo-hexene ring bonded to the pyran unit are disordered over two sets of sites [occupancies = 0.570 (3) and 0.430 (3)]. In the crystal, mol-ecules are linked by C-H⋯O...

The title compound, C16H22Br2O, was synthesized from β-himachalene (3,5,5,9-tetra-methyl-2,4a,5,6,7,8-hexa-hydro-1H-benzocyclo-heptene), which was isolated from the essential oil of the Atlas cedar (Cedrus Atlantica). The mol-ecule is built up from fused six- and seven-membered rings and an additional three-membered ring from the reaction of himachalene with dibromo-carbene. The six-membered ri...

In the title compound, C(23)H(15)ClN(2)O, the fused ring system is planar: the deviation of all the non-H atoms from the plane through all four fused rings is less than 0.31 Å. The plane of the phenyl ring is inclined at 71.78 (5)° to the mean plane of the 1,8-naphthrydine ring system. The crystal structure is devoid of any classical hydrogen bonds but π-π inter-actions are present.

The first synthetic attempt commencing from an eight-membered ring to approach the [5.3.1] bicyclic core of vinigrol has demonstrated the feasibility of using the conformational bias of the cyclooctane-ring system to realize highly diastereoselective reactions. The synthetic potential of the newly disclosed access to in/out isomerism may stimulate broader interests.

The title compound, C(25)H(24)O(3), synthesized as a potential chiral catalyst, exhibits a range of C-C bond lengths in the penta-cyclo-undecane cage between 1.5144 (18) and 1.5856 (16) Å. The two benzene rings are not planar with respect to each other, but rather are twisted at a torsion angle of 34.67 (17)°. The mol-ecule has an intra-molecular O-H⋯O inter-action and participates in two C-H⋯O...