In this review the synthetic work in the field of aphidicolane, stemodane and stemarane diterpenoids, in which readily available (+)-podocarpic acid (4) was used as chiral template for the construction of their polycyclic structures, is described as it developed along the years. In the frame of this work (+)-podocarpic acid (4) was a very useful tool in a model study leading to the syntheses of...

Abstract: Poisonings by psychotropic drugs in various manners pose a serious public health, forensic and clinical medicine problem especially for the medical staff of toxicology, intensive care and anesthesiology wards. Data on hospital admissions secondary to poisonings by chosen psychotropic drugs (T43 according to ICD-10) in the years 2006-2012, made available due to courtesy of the public h...

Synthesis of optically pure a-tert-butyl 0-methyl (2S,3R)-3-ethylhexahydroquinolinate (18) in 54-59% yield from L-aspartic acid was the foundation for a practical synthesis of (+)-vincamine. Conversion of L-aspartic acid to 18 was accomplished via two routes. In the first route, esterification was followed by mono-N-alkylation to attach the three-carbon residue. Nitrogen protection and intramol...

Trypanosoma brucei parasites are kinetoplastid protozoa that devastate the health and economic well-being of millions of people in Africa through the disease human African trypanosomiasis (HAT). New chemotherapy has been eagerly awaited due to severe side effects and the drug resistance issues plaguing current drugs. Recently, there has been an emphasis on the use of medicinal plants worldwide....

The evolution of the synthetic strategy resulting in a total synthesis of vinigrol is presented. Oxidative dearomatization/intramolecular Diels-Alder cycloaddition has served as the successful cornerstone for all of the approaches. Extensive radical cyclization efforts to form the tetracyclic core resulted in interesting and surprising reaction outcomes, none of which could be advanced to vinig...

a graph is called textit{circulant} if it is a cayley graph on a cyclic group, i.e. its adjacency matrix is circulant. let $d$ be a set of positive, proper divisors of the integer $n>1$. the integral circulant graph $icg_{n}(d)$ has the vertex set $mathbb{z}_{n}$ and the edge set e$(icg_{n}(d))= {{a,b}; gcd(a-b,n)in d }$. let $n=p_{1}p_{2}cdots p_{k}m$, where $p_{1},p_{2},cdots,p_{k}$ are disti...

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