A series of neutral anion receptors with one to three thiourea arms were synthesized and their binding to tetrabutylammonium chloride, acetate, and dihydrogen phosphate salts in aqueous DMSO mixtures was examined. The three-armed thiourea host was found to strongly and selectively bind H2PO4(-) even in DMSO solutions containing up to 30% water. This enabled the dihydrogen phosphate salt to be e...

The first example of a transition-metal-catalyzed, meta-selective C-H bromination procedure is reported. In the presence of catalytic [{Ru(p-cymene)Cl2 }2 ], tetrabutylammonium tribromide can be used to functionalize the meta C-H bond of 2-phenylpyridine derivatives, thus affording difficult to access products which are highly predisposed to further derivatization. We demonstrate this utility w...

BACKGROUND/AIMS Iodide efflux from thyroid cells into the follicular lumen is essential for the synthesis of thyroid hormones, however, the pathways mediating this transport have only been partially identified. A calcium-activated pathway of iodide efflux has long been recognized, but its molecular identity unknown. Anoctamin 1 (ANO1) is a calcium-activated chloride channel (CaCC), and this stu...

Perennial ryegrass (S23), timothy (S48), white clover (S100) and red clover (Hungaropoly), grown in culture solutions containing 0.2 x 5.0 x M-potassium iodide, showed relatively small differences in iodine uptake. The lowest uptake occurred with timothy, the species that also produced the lowest yields of dry matter. Red clover had the lowest concentration of iodine in the shoots on all treatm...

NVe studied the inhibitory effect of iodide on thyroid growtlk iR FRTL-5 cells, which pyeserve many thyroid functions, When the amount of iodide in medium exceeds IO-6 M, TSH-stimulated [3H]thymidine incorporation into DNA was sigRificantly inhibited. Methimazole (O.:5 mM> reversed the suppression, as was observed in other functions such as thyroid hormone synthesis and secretion. Cell numbers ...

A new carbon paste electrode (CPE) for the determination of iodide ion based on a cetyltrimethylammonium iodide (CTMAI) ion pair as an electroactive material is described. The electrode shows a linear response for iodide ion over the concentration range of 4 x 10(-5) M to 1 x 10(-1) M with a lower detection limit of 4 x 10(-5) M at 25 degrees C. The electrode has a Nemstian slope of -55.0 +/- 0...

Iodide absorption by fresh, summer Lam inaria digitata frond was accompanied b y about a fivefold increase in the rate o f oxygen consumption. Betw een approxim ately 3 and 6 m ole­ cules o f Oa were consumed for each iodide ion absorbed by the tissue and the respiratory quotient, whether measured in the presence or absence o f iodide, lay between 0*9 and 1*1 (mean 0*94). I t is argued th a t: ...

A new indirect method for the determination of iodide and thiosulfate ions in table salt and milk by flame atomic absorption spectrometry was described. This method is based on the reduction of chromium (VI) to chromium(III) with the reducing action of iodide and/or thiosulfate, separation of unreacted Cr(VI) as its 1,5-diphenilcarbazide complex on a column filled with Amberlite XAD-16, elution...

As a part of studies concerning clinical application of the measurement of urinary iodide with an iodide-selective ion electrode, we report here the reference values for the iodide content or concentration in morning spot urine specimens from normal subjects of varying ages and studies with patients with thyroid diseases in Japan. The number distribution of the iodide content or concentration i...

Active transport of iodide into the thyroid gland is a crucial and rate-limiting step in the biosynthesis of thyroid hormones that play an important role in the metabolism, growth, and maturation of a variety of organ systems, in particular the nervous system (1). Although it has been known for decades that iodide transport into the thyroid gland is mediated by a specific sodium-dependent iodid...