The title triangulo-triruthenium(0) compound, [Ru(3)(C(30)H(32)P(2))(CO)(10)], contains a triangle of singly bonded Ru atoms. The phosphane-bridged Ru-Ru distance [2.9531 (2) Å] is significantly longer than the non-bridged Ru-Ru distances [2.8842 (2) and 2.8876 (2) Å] . The bis-(diphenyl-phosphan-yl)hexane ligand bridges the Ru-Ru bond. Each phosphane-substituted Ru atom bears one equatorial an...

Anhydrous indium trichloride reacts with [2-(Ph2P)C6H4]2PPh (TP) in the molar ratio 2:1 to give an ionic complex [(TP)InCl2]+ InCLin almost quantitative yield. The structure of the product has been determined by a single crystal X-ray diffraction study. In the cation the TP molecule acts only as a bidentate ligand via its two terminal phosphorus atoms [In-Pl 2.5956(8), In-P2 2.5799o(7) A], Alth...

The 39-kDa receptor-associated protein (RAP) is a specialized antagonist that inhibits all known ligand interactions with receptors that belong to the low density lipoprotein (LDL) receptor gene family. Recent studies have demonstrated a role for RAP as a molecular chaperone for the LDL receptor-related protein during receptor folding and trafficking within the early secretory pathway. In the p...

Steroid hormones are important endocrine signalling molecules controlling reproduction, development, metabolism, salt balance and specialized cellular responses, such as inflammation and immunity. They are lipophilic in character and act by binding to intracellular receptor proteins. These receptors function as ligand-activated transcription factors, switching on or off networks of genes in res...

The title binuclear Zn(II) compound, [Zn(2)(C(12)H(9)O(3))(4)(H(2)O)(2)], is centrosymmetric. Each Zn atom is coordinated by two bridging 2-naphthoxyacetate anions, one terminal 2-naphth-oxy-acetate anion and one water mol-ecule in a distorted ZnO(4) tetra-hedral geometry. The naphthalene system of the bridging ligand is nearly perpendicular to the naphthalene of the terminal ligand, with a dih...

CCR6 is a G protein-coupled receptor (GPCR) that recognizes a single chemokine ligand, CCL20 and is primarily expressed by leukocytes. Upon ligand binding, CCR6 activates Gαi heterotrimeric G proteins to induce various potential cellular outcomes through context-specific cell signaling. It is well known that differential phosphorylation of Ser and Thr residues in the C-terminal domains or intra...