BACKGROUND The purpose of this study was to evaluate the safety and efficacy of a long-term, twice-daily brinzolamide 1%/timolol 0.5% fixed combination ophthalmic suspension (BRINZ/TIM-FC) in Japanese patients with open-angle glaucoma (primary open-angle, normal-tension, exfoliation, or pigmentary) or ocular hypertension. METHODS This was a prospective, nonrandomized, multicenter, open-label,...

BACKGROUND The cognitive effects of dopaminergic treatment in Parkinson's disease (PD) are still controversial. OBJECTIVE To evaluate, in previously untreated patients with PD, whether chronic dopaminergic stimulation produces significant cognitive changes; whether they are sustained beyond the period of a few months; and whether the cognitive status of two motor-comparable groups is differen...

Over the past decade, blockchain technology has been actively embraced by an increasing number of companies. Blockchain proven its effectiveness not only in financial sector, but also logistics and supply chain management, received extensive coverage scientific literature. At same time, implementation management (SCM) is technically difficult requires significant costs. In this regard, distribu...

An experimental system for computing robust tests for stuck-open faults in static CMOS circuits is presented. It constructs robust test-pairs from tests for stuck-at faults by identifying several classes of FETs. Robust tests for stuck-open faults in FETs belonging to these classes are constructed from any stuck-at test set by carefully constructing initialization vectors. Initialization vector...

Objective: The present study was carried out to investigate the neuropharmacological activities of ethyl acetate extract of Mimosa pudica (EAMP) leaves on anxiety, depression and memory in a mouse model. Materials and Methods: Anti-anxiety potential of EAMP was evaluated by elevated plus maze (EPM), light-dark box (LDB) and social interaction (SI) tests in mice.Anti-depressant potential of EAMP...

background: the education system requires extensive manpower training of researchers.     moreover, importance of research in developing countries to achieve growth in all fields is irrefutable     . in this study, the attitude, knowledge, and performance of medical and dental students of rafsanjan university of medical sciences on research were assessed. methods: in this descriptive study, 400...

The integration of data elements scattered along different resources, with heterogeneous formats, can take advantage of an approach with progressive and lightweight steps, instead of pursuing costly upfront mappings. To support such approach, we defined a multiscale-based dataspace architecture, called LinkedScales, which carries an integration process via graph-based transformations over a gra...