Osteoporosis is complicated by the occurrence of fragility fractures. Over past years, various treatment options have become available, mostly potent antiresorptive agents such as bisphosphonates and denosumab. However, antiresorptive therapy cannot fully and rapidly restore bone mass and structure that has been lost because of increased remodelling. Alternatively recombinant human parathyroid ...

Glucocorticoids, widely used in inflammatory disorders, rapidly increase bone fragility and, therefore, fracture risk. However, common bone densitometry measurements are not sensitive enough to detect these changes. Moreover, densitometry only partially recognizes treatment-induced fracture reductions in osteoporosis. Here, we tested whether the reference point indentation technique could detec...

BACKGROUND Changes over time in the callus during intermittent administration of parathyroid hormone (PTH) were studied in rabbit distraction osteogenesis models. METHOD Models of distraction osteogenesis in Japanese white rabbits were created, and distraction osteogenesis (total length: 10.5 mm) was performed for 2 weeks. Simultaneously with the start of distraction, 30 rabbits received 4 we...

The number of osteoporotic fractures is increasing worldwide and this is accompanied by increasing disability and medical costs [1,2]. Several antiresorptive treatments, including bisphosphonates, decrease bone resorption (but also decrease bone formation), and reduce the risk of vertebral fractures, which occur in 35–70% of trabecular bone. However, nonvertebral fractures that typically occur ...

Glucocorticoids (GC)-induced osteoporosis (GIOP) is the most common cause of secondary osteoporosis, which leads to an increased fracture risk in patients. The normal bone turnover depends on a balance between osteoblasts and osteoclasts activity and GC can cause a rapid bone loss, decreasing bone formation and increasing bone resorption. The decreased bone formation is mainly due to the GC-ind...

Osteoporosis is a disease characterized by low bone mass with micro architectural deterioration of bone tissue leading to enhance bone fragility. This increases the susceptibility to fracture. Osteoporosis is a major public health problem. Hip fractures are the most devastating consequence of osteoporosis. Osteoporosis is essentially an asymptomatic disease. Medical evaluation includes complete...

OBJECTIVE Osteoporosis represents the most common metabolic disease of bone, with an estimated 10% adults aged 50 years or older affected in United States. This patient population is at increased risk for spine fracture and instrumentation-related complications after surgery. Surgeon knowledge available treatments patients low bone mineral density (BMD) how they impact biology fusion may help m...