نتایج جستجو برای: tenecteplase
تعداد نتایج: 297 فیلتر نتایج به سال:
BACKGROUND AND PURPOSE Recombinant tissue-type plasminogen activator (rtPA) is the only approved treatment in acute ischemic stroke. However, intracerebral hemorrhage (ICH) occurs in 6.4% of patients treated with rtPA and limits its use. Tenecteplase (TNK) is a modified form of rtPA, with longer half-life and greater fibrin specificity. Patients after myocardial infarction had fewer systemic he...
TNKase is a genetically engineered variant of the alteplase molecule. Three different mutations result in an increase of the plasma half-life, of the resistance to plasminogen-activator inhibitor 1 and of the thrombolytic potency against platelet-rich thrombi. Among available agents in clinical practice, TNKase is the most fibrin-specific molecule and can be delivered as a single bolus intraven...
Among the ≈700 000 ischemic strokes per year in North America, most (≤70%) are minor and initially nondisabling presenting with transient or persistent minor stroke symptoms (transient ischemic attack or minor stroke). However, this seemingly mild presentation is misleading because the prognosis is not benign. Multiple studies have reported that among patients considered too mild for thrombolys...
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