Penicillin G acylase from E. coli TA1 was immobilized by Cross-Linked Enzyme Aggregates (CLEA), a new method for immobilization. This biocatalyst and commercial immobilized penicillin G acylase (PGA-450) were used to study the effect of pH, temperature and substrate concentration on the synthesis of ampicillin from phenyl glycine methyl ester (PGME) and 6-aminopenicillanic acid (6-APA). Compare...

One-pot four-component synthesis of polyfunctionalized 1,4-dihydropyridine derivatives was developed by a condensation of aldehydes, malononitrile, diethylacetylenedicarboxylate and aniline in the presence of choline chloride/urea as a deep eutectic solvent (DES)at room temperature.Moreover, an efficient method was reported for the synthesis of highly substituted 4H-chromenes through one-...

A  new  and  efficient  synthesis  of  2-amino-4H-chromene  derivativeswhich  have remarkable pharmacological properties  is  developed  by  one-pot  three-component  efficient  reaction  between aldehydes, malononitrile, and α or β-naphthol in MeOH as solvent using DABCO-CuCl complex as an  effective  catalyst  at  room  temperature. The  structures of  synthesized  compounds  were characteriz...

The study of hydrogels and their response to external environment is of special interest because of their potential as drug delivery systems,1,2 actuators,3 and separation devices.4,5 Temperature-sensitive hydrogels undergo a reversible swellingdeswelling transition with a small change of temperature near the phase transition point.6 A frequently studied thermosensitive hydrogel is based on sol...

Phase-pure BiCuOSe, which is isostructural to the layered p-type transparent conductor LaCuOS, has been synthesized in high yield by a single-step hydrothermal reaction at low temperature (250 degrees C) and pressure (<20 atm). A moderate reaction temperature of 250 degrees C was sufficiently high to solubilize both Bi2O3 and Cu2O and stabilize monovalent copper and low enough to impede the oxi...

Some issues such as tunneling, leakage current and light atom penetration through the film are threatening the ultra thin SiO2 be as a good dielectric for future industrial and electronic devices. Moreover, ultra fine and pure ZrO2/CrO2 are also so important in ceramic technologies. We have demonstrated a series of experiments to synthesis ZrO2 as well as CrO2 at low temperature with using sol-...

A facile and one-pot multicomponent synthesis of novel 1,4-disubstituted-1H-1,2,3-triazoles from alkenes at room temperature is reported. At the first step, in the presence of I2/NaN3 reagents, various alkenes were converted to the corresponding azido iodides and in the next step, the reaction of these compounds with phenylacetylene in the presence of catalytic amount of sodium ascorbate/ CuSO4...

Modeling and optimization of synthesis gas production via the non-catalytic partial oxidation of methane (NCPO) were studied by minimizing of Gibbs free energy, and comparison studies were carried out to analyze the mechanism of syngas production. For this purpose, concentrations of CO2 and H2O in the feed were optimized in specified pressure and temperature, such that the hydrogen to carbon mo...

The effect of cooling process for the synthesis and the superconductivity properties of Pb-substituted Bi-based materials, has been investigated. The preparation condition for the formation of (2,2,2,3) phase has been examined. The influence of thermal condition of the synthesis and quenching on the critical temperature and the content of 110K phase was investigated. Results of the ac-susceptib...