OBJECTIVES To investigate appropriate antimicrobial agents, the optimal concentration and treatment duration for the antibiotic lock technique (ALT) to treat catheter-related infections caused by Staphylococcus epidermidis and Staphylococcus aureus. METHODS We evaluated the bacterial killing activity of vancomycin, teicoplanin, ciprofloxacin, rifampicin, cefazolin, gentamicin, nafcillin and e...

Of 55 MRSA, 47 isolates were biofilm producers and 8 isolates were non-biofilm producers. Of 47 biofilm producers, 24 (51.0%), 14 (29.8%) and 9 (19.1%) produced strong (OD570 ≥ 0.5), medium (OD570 ≥ 0.2 to <0.5), weak (OD570 0 to <0.2) biofilm, respectively. Of the 47 isolates, eight determinants (genes) (eno, hla, hlb, clfA, fnaA, icaA, agrII and sar) were found predominantly among 70 to 80% i...

Zeliha KOÇAK TUFAN*, Hatice Rahmet GÜNER, Gülruhsar YILMAZ, Aybegüm ÖZŞAHİN, Murat BOZKURT, Mehmet Akın TAŞYARAN Department of Infectious Diseases and Clinical Microbiology, Ankara Atatürk Training and Research Hospital, Yıldırım Beyazıt University, Bilkent, Ankara, Turkey Department of Orthopedics and Traumatology, Ankara Atatürk Training and Research Hospital, Yıldırım Beyazıt University, Bil...

Basic hydrolyses carried out on the glycopeptide antibiotic teicoplanin or its acidic hydrolysis products give rise to epimeric species which retain little antibiotic activity. The detailed structure of a sample epimer has been determined using 1H NMR spectroscopy.

and specific detection of verotoxin genes in Escherichia coli by the polymerase chain reaction. TE. Detection and characterization of the eae gene of Shiga-like toxin-producing Escherichia coli using polymerase chain reaction. To the Editor: Staphylococcal isolates with reduced susceptibility to glycopeptides, such as vancomycin and teicoplanin, are a serious public health problem because staph...

Bone and joint infections are significant causes of morbidity, mortality and healthcare costs. The cost of treatment for such infections is driven primarily by the length of hospital stay. Many of these infections will require treatment with prolonged periods of parenteral antibiotic therapy. Clinicians and healthcare managers are being attracted increasingly by administering treatment in the a...

AIMS To identify and determine antibiotic susceptibility of coagulase negative staphylococci (CoNS) isolated from patients with chronic blepharitis, purulent conjunctivitis, and suppurative keratitis. METHODS A retrospective review of all culture positive cases of chronic blepharitis, purulent conjunctivitis, and suppurative keratitis between July 1995 and December 1996 was performed. Cases i...