Tamoxifen (TAM) resistance has become a severe problem for endocrine therapy of breast cancer. The present study investigated the association between microRNA (miRNA) expression and TAM resistance in breast cancer. The TAM-resistant breast cancer MCF-7C and MCF-7T cell lines were established using the human breast cancer cell line MCF-7 as the parental cell line and 4-hydroxytamoxifen (OHT) as ...

This paper examines previous Technology Acceptance Model (TAM)-related studies in order to provide an expanded model that explains consumers’ acceptance of online purchasing. Our model provides extensions to the original TAM by including constructs such as social influence and voluntariness; it also examines the impact of external variables including trust, privacy, risk, and e-loyalty. We surv...

Information Technology plays an important role in improving organizational competitiveness and as a result the economic growth of a country, particularly within the emerging context. This research in progress examines the extent of information communication technology (ICT) skills, use and adoption among owners of small and medium enterprises (SMEs) in Morocco. The framework for this analysis i...

While most banks in the UAE have adopted the Internet in providing various services, the understanding of the user acceptance of e-banking services remains limited. Prior studies on ebanking acceptance have been mainly conducted in the western countries. Given the different population and culture in the UAE from the western countries, it is necessary to identify the factors that are more releva...

Conventional use of the site-specific recombinase Cre is a powerful technology in mouse, but almost absent in other vertebrate model organisms. In zebrafish, Cre-mediated recombination efficiency was previously very low. Here we show that using transposon-mediated transgenesis, Cre is in fact highly efficient in this organism. Furthermore, temporal control of recombination can be achieved by us...

This paper presents a novel acceptance model for scenarios in which people make use of mobile devices for leisure purposes. The use of mobile devices has such a dominant leisure component that user attitudes towards mobile adoption are strongly determined. Since hedonic aspects play a key role in mobile adoption, they are introduced through the constructs in the proposed Technology Acceptance M...

This paper studies the impact of sales promotion on consumers’ intention to purchase online in the setting of a consumer-to-consumer (C2C) marketplace. The research is grounded in the theory of Technology Acceptance Model (TAM). We test a number of hypotheses empirically about the relationship between online sales promotion, TAM and C2C online purchasing intention. The finding of this study sug...

The proliferation of information technology (IT) in supporting highly specialized tasks and services has made it increasingly important to understand the factors essential to technology acceptance by individuals. In a typical professional setting, the essential characteristics of user, technology, and context may differ considerably from those in ordinary business settings. This study examined ...

Individual behavior in technology adoption can be predicted by perception and belief. Implementing TAM, this study aims to analyze the behavioral teaching staff using Google Apps for online learning. This examined effect of perceived usefulness, ease use, user training support on intention use technology. We analyzed 108 samples SPSS Process Model 4 15 examine mediation moderated effect. Our re...

This study concentrates on the role of personal traits in technology acceptance by comparing which of the two personal trait constructs commonly used in IS research, personal innovativeness in the domain of information technology (PIIT) or technology readiness ind...