Chemical modifications of innate DNA/RNA aptamers facilitate the improvement their function. Herein, we report our modular strategy to manipulate a thrombin-binding DNA aptamer (TBA) improve its anticoagulation activity and binding affinity. A set amino acid conjugates, termed acid–nucleic hybrids or ANHs, was synthesized incorporated into TBA loop sequences. We found that substitutions with hy...

This study is focused on the effect of phycobiliprotein extraction Gracilaria quality common carp burgers, and application nanoliposomes containing pigment in improvement its antimicrobial antioxidant activity burgers during refrigerated storage 18 days. Burgers were incorporated with liposomal (2.5% 5% w/w), their chemical microbial changes terms pH, peroxide value (PV), thiobarbituric acid (T...

The present study was undertaken to evaluate the effect of different levels (0%, 20%, 25%, and 30%) wheat flour on quality characteristics chicken meatball. After formulation, samples were stored at -20˚C temperature for 60 days analyzed 15th day, 30th 45th day 60th day. products various sensory (color, flavor, texture, Juiciness, tenderness, overall acceptability), physicochemical (proximate a...

We supplemented diets with α-tocopheryl acetate (100 mg/kg) and replaced beef tallow (BT) in feeds with increasing doses of n-6- or n-3-rich vegetable fat sources (linseed and sunflower oil), and studied the effects on the fatty acid (FA) composition, the α-tocopherol (αT) content and the oxidative stability of rabbit plasma and liver. These effects were compared with those observed in a previo...

Nelson's syndrome is a potentially life-threatening condition which occurs when an adrenocorticotrophic hormone (ACTH) secreting tumour develops following therapeutic total bilateral adrenalectomy (TBA) for Cushing's disease. First described in 1958, it can develop as long as 24 years post-TBA but the mean is 15 years. [2]When the first cases were described the mortality rate was 12% but this h...