Cysteine residues in cytosolic proteins are maintained in their reduced state, but can undergo oxidation owing to posttranslational modification during redox signaling or under conditions of oxidative stress. In large part, the reduction of oxidized protein cysteines is mediated by a small 12-kDa thiol oxidoreductase, thioredoxin (Trx). Trx provides reducing equivalents for central metabolic en...

Sequence-specific DNA-binding proteins must quickly and reliably localize specific target sites on DNA. This search process has been well characterized for monomeric proteins, but it remains poorly understood for systems that require assembly into dimers or oligomers at the target site. We present a single-molecule study of the target-search mechanism of protelomerase TelK, a recombinase-like p...

Introduction:Holmium-166 radionuclide is one of the most effective radionuclides used for targeted therapy with theranostic properties. One method to produce this radioisotope is via the decay of its parent (indirect method). In this study applicability of extraction chromatography (EXC) for separation of no carrier added 166Ho from neutron-irradiated natura...

Predicting a realistic target yield is one of the critical problems in precision farming. An artificial neural network was employed to model the nonlinear relationship between cotton yield and the factors influencing yield. Using sixyear field data obtained from LuoYang Dry Land Research Center, the neural network model was developed and trained, and the RMSE for test data was 3.70%. The result...

Inspired by the discovery of dimeric motor proteins capable of undergoing transportation in living cells, significant efforts have been expended recently to the fabrication of track-walking nanomotors possessing two foot-like components that each can bind or detach from an array of anchorage groups on the track in response to local events of reagent consumption. The central problem in fabricati...

The target tracking is one of the main issues in wireless sensor networks (WSNs). In the WSNs, the energy consumption is the most important factor for the network lifetime. In this paper, we utilize the advantage of the grid-based sensor networks to prolong the lifetime of the network. Therefore, we propose Grid-based Mobile Target Tracking Mechanism in Wireless Sensor Networks (GMTT). By the s...

Cancer as a disease in the human population is becoming a larger health problem, and the medicines used as treatments have clear limitations. In the past 20 years, there has been a tremendous increase in our knowledge of the molecular mechanisms and pathophysiology of human cancer. Many of these mechanisms have been exploited as new targets for drug development in the hope that they will have g...

Switchgrass (Panicum virgatum L.) has been developed into a dedicated herbaceous bioenergy crop. Biomass yield is a major target trait for genetic improvement of switchgrass. microRNAs have emerged as a prominent class of gene regulatory factors that has the potential to improve complex traits such as biomass yield. A miR156b precursor was overexpressed in switchgrass. The effects of miR156 ove...