accurate calculation of reliability index is very important for the reliability analysis of structures. in some limit state functions with nonlinear characteristic and several local optimum design points, the computational reliability methods may not appropriately determine the failure probability, and iterative reliability approaches may be converged to local optimum design points. in this pap...

We studied the dynamics of voluntary, horizontal, binocular gaze-shifts between pairs of continuously visible, real three-dimensional targets. Subjects were stabilized on a biteboard to allow full control of target angles, which were made to differ only in distance (pure vergence), only in direction (pure version; conjugate saccades) or in both distance and direction (disjunctive saccades). A w...

The Conjugate Gradient Method is a numerical optimization technique that finds the optimal solution by focusing on coefficient conjugate. This paper presents new coefficients conjugate gradient method for removing impulse noise from images, which based quadratic function and proven to be globally convergent. Results show it an effective image restoration.

The n-tuple of Laplacian characteristic values of a graph is majorized by the conjugate sequence of its degrees. Using that result we find a collection of general inequalities for a number of Laplacian indices expressed in terms of the conjugate degrees, and then with a maximality argument, we find tight general bounds expressed in terms of the size of the vertex set n and the average degree dG...

In DEMO, the divertor must endure steady state loads of 10 MW m−2 and transient thermal cycling up to 20 m−2. A novel target, termed Spiral Plate Module (SPM) designed meet these loads, was initially optimized by a one-dimensional, steady-state model. The best design trade-off between wall overheat (τs)—a figure merit for cooling performanceand pumping ratio (ηP)—a comparison pressure drop inci...

A novel target specific small interfering RNA (siRNA) delivery system was successfully developed using polyethyleneimine (PEI)-hyaluronic acid (HA) conjugate. Anti-PGL3-Luc siRNA was used as a model system suppressing the PGL3-Luc gene expression. The siRNA/PEI-HA complex with an average size of ca. 21 nm appeared to be formed by electrostatic interaction between the negatively charged siRNA an...

Although many breast and lung cancers overexpress human epidermal growth factor receptor-2 (HER-2), no methods currently exist for effective and early detection of HER-2-positive cancers. To address this issue, we designed and synthesized dendrimer-based novel nano-imaging agents that contain gold nanoparticles (AuNPs) and gadolinium (Gd), conjugated with the humanized anti-HER-2 antibody (Herc...

T-cell-mediated cytolysis is initiated by the formation of strong adhesions between killer and target cells. The present work was aimed at determining whether T lymphocytes might exert some mechanical stress on targets during the binding process. Target S194 myeloma cells were thus conjugated to cytotoxic T lymphocytes (CTLs) raised by mixed lymphocyte culture or a cloned lymphoid line that was...