نتایج جستجو برای: tap1
تعداد نتایج: 418 فیلتر نتایج به سال:
Dendritic cells (DCs) express several receptors for the Fc portion of immunoglobulin (Ig)G (FcgammaR), which mediate internalization of antigen-IgG complexes (immune complexes, ICs) and promote efficient major histocompatibility complex (MHC) class II-restricted antigen presentation. We now show that FcgammaRs have two additional specific attributes in murine DCs: the induction of DC maturation...
Signal transducers and activators of transcription 1 (STAT1) is a critical mediator of interferon (IFN)-induced gene responses. Recently, STAT1 was found to become modified by small ubiquitin-like modifier 1 (SUMO-1) conjugation at Lys703 through the SUMO E3 ligase function of protein inhibitors of activated STAT (PIAS) proteins. However, the physiologic function of sumoylation in STAT1 is stil...
Tapasin organizes the peptide-loading complex (PLC) by recruiting peptide-receptive MHC class I (MHC-I) and accessory chaperones to the N-terminal regions of the TAP subunits TAP1 and TAP2. Despite numerous studies have shown that the formation of the PLC is essential to facilitate proper MHC-I loading, the molecular architecture of this complex is still highly controversial. We studied the sto...
The notation and terminology used here are introduced in the following papers: [1], [5], [12], [4], [9], [14], [13], [8], [15], [6], [2], [3], [7], [11], and [10]. We follow the rules: a, a1, a2, a3, b, b1, b2, b3, r, s, t, u are real numbers, n is a natural number, and x0, x, x1, x2, x3, y0, y, y1, y2, y3 are elements of R . One can prove the following propositions: (1) s t · (u · x) = s·u t ·...
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