Background and aim: Tanacetum parthenium L. is herbaceous perennial medicinal plant belonging to the Asteraceae family. Feverfew is used as an analgesic, housing, fever-lowering, anti-rheumatism and migraines in traditional medicine. The most important active ingredient of the herb is essential oil. Variation on genetic and environmental conditions play a major role in...

Background and aim: Tanacetum parthenium L. is herbaceous perennial medicinal plant belonging to the Asteraceae family. Feverfew is used as an analgesic, housing, fever-lowering, anti-rheumatism and migraines in traditional medicine. The most important active ingredient of the herb is essential oil. Variation on genetic and environmental conditions play a major role in...

Parthenolide (PN) is the principal sesquiterpene lactone in feverfew (Tanacetum parthenium) with proven anti-inflammatory properties. We have previously reported that PN possesses strong anticancer activity in ultraviolet B (UVB)-induced skin cancer in SKH-1 hairless mice. In order to further understand the mechanism(s) involved in the anticancer activity of PN, we investigated the role of prot...