Human CD38 is a type II transmembrane glycoprotein that regulates lymphocyte adhesion, proliferation, and cytokine production. The mAb Moon-1 recognizes a ligand for CD38 (CD38L) and specifically inhibits CD38-mediated cell adhesion. To analyze the role of CD38 and its ligand in MHC-nonrestricted T cell activation, we examined the effects of Moon-1 and the anti-CD38 mAb IB4 on the effector func...

Almost every theory of vagueness shares at least one feature: it uses, and in most cases heavily relies on, some kind of normative predicate (or predicates) in its metalanguage. Metalinguistic normative predicates are discussed chiefly by supervaluationists and other defenders of higher-order vagueness. According to this group of theorists, the existence of higher-order vagueness depends on and...

The daily BW gain of stocker steers grazing tall fescue [Lolium arundinaceum (Schreb.) S.J. Darbysh. = Schedonorus arundinaceus (Schreb.) Dumort.]-based pastures typically declines during summer. To avoid these declines, in part to mitigate the effects of tall fescue toxicosis, it is commonly advised to move cattle to warm-season forage during this period. A 3-yr (2006, 2007, and 2008) grazing ...

The notch signaling pathway is highly conserved and plays an important role in the regulation of cellular proliferation, differentiation and apoptosis. Constitutive activation of notch signaling results in excessive cellular proliferation and a wide range of malignan-cies. However, notch can also act as a tumor suppressor, and its inactivation has been associated with an increased risk of spont...

The notch signaling pathway is highly conserved and plays an important role in the regulation of cellular proliferation, differentiation and apoptosis. Constitutive activation of notch signaling results in excessive cellular proliferation and a wide range of malignan-cies. However, notch can also act as a tumor suppressor, and its inactivation has been associated with an increased risk of spont...

To cite: Lambert BL, Schroeder SR, Galanter WL. BMJ Qual Saf 2016;25: 213–217. Wrong-drug errors, thought to be caused primarily by drug names that look and/or sound alike, occur at a rate of about one error per thousand dispensed prescriptions in the outpatient setting and one per thousand orders in the inpatient setting. 2 Most are relatively benign, but some cause severe or even fatal harm. ...

When a building is located in an urban area, it is exposed to a wind of different characteristics then wind over an open terrain. This is development of turbulent wake region behind an upstream building. The interaction with upstream building can produce significant changes in the response of the tall building. Here, in this paper, an attempt has been made to study wind induced interference eff...

As a testbed for various structural health monitoring (SHM) technologies, a super-tall structure – the 610 m-tall Guangzhou Television and Sightseeing Tower (GTST) in southern China – is currently under construction. This study aims to explore state-of-the-art wireless sensing technologies for monitoring the ambient vibration of such a super-tall structure during construction. The very nature o...

AIMS To compare the prevalence of faecal shedding of Escherichia coli O157:H7 and Salmonella in growing beef cattle consuming various forages. METHODS AND RESULTS In Experiment I, faecal samples were collected from steers grazing either endophyte-infected (E+) tall fescue or common bermudagrass (CB). Steers grazing E+ tall fescue were confined to a dry-lot pen and fed CB hay ad libitum for 10...

potassium (k) is an essential element for plant growth and development and its importance in agriculture is well known. it plays an important role in improving the quality of agricultural products. besides, micaceous minerals are abundant in iranian soils. the role of plant species in potassium uptake from minerals is significant; but not well investigated. therefore, the objective of this rese...