BACKGROUND Hybanthus enneaspermus (HE) leaves are being used traditionally to relieve pain, and scientific studies have demonstrated their analgesic potential. This study attempted to elucidate the pharmacological mechanism(s) involved in the analgesic action of ethanol extract of H. enneaspermus leaves (EEHE). MATERIALS AND METHODS Forty-two male Wistar rats were separately randomized into s...

Ten new synthetic thiazolidine-4-ones derivatives (5 chlorothiazolidine-4-ones, 3 methoxythiazolidine-4-ones and 2 hydoxythiazolidine-4-ones) having different substituents at R1, R2 and R3 were evaluated for their analgesic activity using different animal models and their structure activity relationship was also elucidated. Chlorothiazolidine-4-ones and methoxythiazolidine-4-ones exhibited anal...

objective(s):   recently, applications of mno2 nanoparticles and microparticles in industry, pharmacology, and medicine have considerably expanded. mn distribution and clearance from brain and spinal cord tissue compared with muscle tissue of rats after single subcutaneous injection of nanoparticles and microparticle of mno2. pain sensory threshold of rat was evaluated as neurologic consequence...

SUMMARY Adult male Sprague-Dawley rats briefly immersed-n cold water and forced to swim showed Straub tail elevation, a typical s~gn of opiate stimu-iation, upon removal. The presence of Straub tail was a function of degree of immersion and was reversed by naloxone. Th~s suggests the Straub taft response may be a novel behavioral index of stress-indu~ed endorphin release. Stressful manipulation...

Topical drugs avoid many of the problematic side effects of systemic agents. Immersion of the tail of a mouse into a solution of dimethyl sulfoxide (DMSO)-containing morphine produces a dose-dependent, naloxone-sensitive, analgesia (ED(50) 6.1 mM; CL 4.3, 8.4) limited to the portion of the tail exposed to the drug. DMSO alone in this paradigm had no analgesic activity. Like morphine, the opioid...

This paper presents cutting force prediction algorithm for low immersion end-milling, using an efficient dynamic force modeler. The geometric simulation of milling process was performed, using the B-Rep solid modeling techniques. For predicting stability lobes, two methods were used for prediction of stability lobes: the frequency domain technique and the time finite element analysis (TFEA). Th...

on the capacity of tissue elements to strain metachromatically. Surprising as it may seem, adequately fixed and dehydrated tissues withstand five minutes' immersion in concentrated sulphuric acid without charring or showing any severe disturbance of their structure. Subsequent staining with a metachromatic dye reveals that a greatly increased range of tissue elements shows a metachromatic affin...

Tele-immersion is a technology that augments your space with real-time 3D projections of remote spaces thus facilitating the interaction of people from different places in virtually the same environment. Tele-immersion combines 3D scene recovery from computer vision, and rendering and interaction from computer graphics. We describe the realtime 3D scene acquisition using a new algorithm for tri...

BACKGROUND Cryotherapy has been associated with a significant decrease in nerve conduction velocity and muscle contraction with possible effects on exercise and physical training. OBJECTIVES To quantify the electromyographic response of the lateral gastrocnemius, tibialis anterior, fibularis longus, rectus femoris and gluteus medius to ankle inversion following cold water immersion. METHOD ...